Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy

Zheng, Heng1,2; Chen, Xianxian3; Li, Qiyang3; Liu, Yuqi3; Cai, Jinzhong1,3

2023-02-02

10.3389/fimmu.2023.1084926

Frontiers in Immunology   Impact Factor & Quartile

1664-3224

Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity that can promote tumorigenesis and development, and different types of tumors have different tumor microbiotas, which has important implications for tumor research, detection, and clinical treatment. In this review, we examine the diversity of the tumor microbiota, discuss the impact of chemotherapy and immunotherapy on tumor microbiota diversity, and summarize recent advances in the use of genetically engineered bacteria for the treatment of tumors. In addition, we propose key questions that need to be further addressed by the tumor microbiota.

tumor microbiome chemotherapy immunotherapy engineered bacteria

SCI

English

Corresponding

Immunology

Immunology

WOS:000930962700001

FRONTIERS MEDIA SA

Web of Science

1.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan, Peoples R China
2.Wuhan Univ Technol, Sch Resources & Environm Engn, Wuhan, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Intervent Radiol, Shenzhen, Peoples R China

Zheng, Heng,Chen, Xianxian,Li, Qiyang,et al. Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy[J]. Frontiers in Immunology,2023,14.

Zheng, Heng,Chen, Xianxian,Li, Qiyang,Liu, Yuqi,&Cai, Jinzhong.(2023).Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy.Frontiers in Immunology,14.

Zheng, Heng,et al."Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy".Frontiers in Immunology 14(2023).