| Title | Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma |
| Author | |
| Corresponding Author | Liu, Ranyi; Han, Hui |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 0945-6317
|
| EISSN | 1432-2307
|
| Abstract | Penile squamous cell carcinoma (PSCC) with a poor prognosis lacks reliable biomarkers for stratifying patients. Fas-associated death domain (FADD) could regulate cell proliferation and has shown promising diagnostic and prognostic significance in multiple cancers. However, researchers have not determined how FADD exerts its effect on PSCC. In this study, we set out to investigate the clinical features of FADD and the prognostic impact of PSCC. Additionally, we also assessed the role of affecting the immune environment in PSCC. Immunohistochemistry was carried out to evaluate the protein expression of FADD. The difference between FADD(high) and FADD(low) was explored by RNA sequencing from available cases. The immune environment evaluation of CD4, CD8, and Foxp3 was performed by immunohistochemical. In this study, we found that FADD was overexpressed in 19.6 (39/199) patients, and the overexpression of FADD was associated with phimosis (p=0.007), N stage (p<0.001), clinical stage (p=0.001), and histologic grade (p=0.005). The overexpression of FADD was an independent prognostic factor for both PFS (HR 3.976, 95% CI 2.413-6.553, p<0.001) and OS (HR 4.134, 95% CI 2.358-7.247, p<0.001). In addition, overexpression of FADD was mainly linked to T cell activation and PD-L1 expression combined with PD-L1 checkpoint in cancer. Further validation demonstrated that overexpression of FADD was positively correlated with the infiltration of Foxp3 in PSCC (p=0.0142). It is the first time to show that overexpression of FADD is an adjunct biomarker with poor prognosis in PSCC and could also serve as a tumor immune environment regulator. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| WOS Research Area | Pathology
|
| WOS Subject | Pathology
|
| WOS Accession No | WOS:000935235800001
|
| Publisher | |
| ESI Research Field | CLINICAL MEDICINE
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/490013 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, Dept Urol, State Key Lab Oncol South China,Canc Ctr, Guangzhou 510060, Peoples R China 2.Guizhou Prov Peoples Hosp, Dept Med Oncol, Guiyang, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Urol, Affiliated Hosp 1, Shenzhen 518060, Peoples R China 4.Sun Yat Sen Univ, Dept Pathol, Canc Ctr, Guangzhou 510060, Peoples R China 5.Sun Yat Sen Univ, Dept Radiol, Canc Ctr, Guangzhou 510060, Peoples R China 6.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gen Surg, Guangzhou 510080, Peoples R China |
| Recommended Citation GB/T 7714 |
Xue, Ting,Yan, Ru,Li, Zaishang,et al. Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma[J]. VIRCHOWS ARCHIV,2023.
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| APA |
Xue, Ting.,Yan, Ru.,Li, Zaishang.,Guo, Shengjie.,Xiao, Xiao.,...&Han, Hui.(2023).Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma.VIRCHOWS ARCHIV.
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| MLA |
Xue, Ting,et al."Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma".VIRCHOWS ARCHIV (2023).
|
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