Correlations of Computed Tomography Measurement of Distal Pulmonary Vascular Pruning with Airflow Limitation and Emphysema in COPD Patients

Tang, Guoyan1; Wang, Fengyan1; Liang, Zhenyu1; Liang, Cuixia2; Wang, Jinling3; Yang, Yuqiong1; Tang, Wanyi1,4; Shi, Weijuan1; Tang, Guoqiang3; Yang, Kai5; Wang, Zihui1; Li, Qiasheng1; Li, Hualin1; Xu, Jiaxuan1; Chen, Deyan2; Chen, Rongchang5

2022

10.2147/COPD.S362479

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE   Impact Factor & Quartile

1178-2005

["Background: Pulmonary vascular alteration is an important feature of chronic obstructive pulmonary disease (COPD), which is characterized by distal pulmonary vascular pruning in angiography. We aimed to further investigate the clinical relevance of pulmonary vasculature in COPD patients using non-contrast computed tomography (CT).","Methods: Seventy-one control subjects and 216 COPD patients completed the questionnaires, spirometry, and computed tomography (CT) scans within 1 month and were included in the study. Small pulmonary vessels represented by percentage of cross-sectional area of pulmonary vessels smaller than 5 mm(2) or 5-10 mm(2) to the total lung fields (%CSA<5 or %CSA5-10, respectively) were measured using ImageJ software. Spearman correlation was used to investigate the relationship between %CSA<5 and airflow limitation. A receiver operating characteristic (ROC) curve was built to evaluate the value of %CSA<5 in discriminating COPD patients from healthy control subjects. Segmented regression was used to analyze the relationship between %CSA<5 and %LAA-950 (percentage of low-attenuation areas less than -950 HU).","Results: We found a significant correlation between %CSA<5 and forced expiratory volume in one second (FEV1) percentage of predicted value (% pred) (r = 0.564, P < 0.001). The area under the ROC curve for the value of %CSA<5 in distinguishing COPD was 0.816, with a cut-off value of 0.537 (Youden index J, 0.501; sensitivity, 78.24%; specificity, 71.83%). Since the relationship between %CSA<5 and %LAA-950 was not constant, performance of segmented regression was better than ordinary linear regression (adjusted R-2, 0.474 vs 0.332, P < 0.001 and P < 0.001, respectively). As %CSA<5 decreased, %LAA-950 slightly increased until an inflection point (%CSA<5 = 0.524) was reached, after which the %LAA-950 increased apparently with a decrease in %CSA<5.","Conclusion: %CSA<5 was significantly correlated with both airflow limitation and emphysema, and we identified an inflection point for the relationship between %CSA<5 and %LAA-950."]

computed tomography pulmonary vascular pruning airflow limitation emphysema chronic obstructive pulmonary disease

SCI

English

Corresponding

National Key R&D Program of China["2017YFC1310600","2018YFC1311900"] ; Medical Scientific Research Foundation of Guangdong Province["C2019001","A2019459"] ; National Natural Science Foundation of China[82170042] ; Shenzhen Science Technology and Innovative commission[KCXFZ202002011008256] ; Science and Technology Program of Guangzhou[202201020451]

Respiratory System

Respiratory System

WOS:000932093900001

DOVE MEDICAL PRESS LTD

Web of Science

1.Guangzhou Med Univ, State Key Lab Resp Dis, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, Guangzhou, Peoples R China
2.Neusoft Med Syst Co Ltd, Shenyang, Peoples R China
3.Qingyuan Chron Dis Prevent Hosp, Qingyuan Occupat Dis Prevent Hosp, Qingyuan, Peoples R China
4.Guangzhou Med Univ, Qingyuan Peoples Hosp, Affiliated Hosp 6, Guangzhou, Peoples R China
5.Jinan Univ, Southern Univ Sci & Technol, Dept Resp & Crit Care Med,Shenzhen Inst Resp Dis, Clin Med Coll 2,Affiliated Hosp 1,Shenzhen People, Shenzhen, Peoples R China

Tang, Guoyan,Wang, Fengyan,Liang, Zhenyu,et al. Correlations of Computed Tomography Measurement of Distal Pulmonary Vascular Pruning with Airflow Limitation and Emphysema in COPD Patients[J]. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,2022,17.

Tang, Guoyan.,Wang, Fengyan.,Liang, Zhenyu.,Liang, Cuixia.,Wang, Jinling.,...&Chen, Rongchang.(2022).Correlations of Computed Tomography Measurement of Distal Pulmonary Vascular Pruning with Airflow Limitation and Emphysema in COPD Patients.INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,17.

Tang, Guoyan,et al."Correlations of Computed Tomography Measurement of Distal Pulmonary Vascular Pruning with Airflow Limitation and Emphysema in COPD Patients".INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 17(2022).