Title | Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis |
Author | |
Corresponding Author | Huang,Kai; Chen,Yonglong; Li,Li; Hou,Chunhui |
Joint first author | Shi,Zhaoying; Xu,Jinsheng; Niu,Longjian; Shen,Wei; Yan,Shuting |
Publication Years | 2023-03-28
|
DOI | |
Source Title | |
EISSN | 2211-1247
|
Volume | 42Issue:3 |
Abstract | Transposable elements (TEs) are abundant in metazoan genomes and have multifaceted effects on host fitness. However, the mechanisms underlying the functions of TEs are still not fully understood. Here, we combine Hi-C, ATAC-seq, and ChIP-seq assays to report the existence of multimegabase supersized loop (SSL) clusters in the Xenopus tropicalis sperm. We show that SSL anchors are inaccessible and devoid of the architectural protein CTCF, RNA polymerase II, and modified histones. Nearly all SSL anchors are marked by Helitrons, a class II DNA transposon. Molecular dynamics simulations indicate that SSL clusters are likely formed via a molecular agent-mediated chromatin condensation process. However, only slightly more SSL anchor-associated genes are expressed at late embryo development stages, suggesting that SSL anchors might only function in sperm. Our work shows an evolutionarily distinct and sperm-specific genome structure marked by a subset of Helitrons, whose establishment and function remain to be explored. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | First
; 共同第一
; Corresponding
|
Scopus EID | 2-s2.0-85148667788
|
Data Source | Scopus
|
Citation statistics |
Cited Times [WOS]:0
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/497241 |
Department | Department of Biology 生命科学学院 南方科技大学医学院_公共卫生及应急管理学院 |
Affiliation | 1.Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 2.Department of Bioinformatics,Huazhong Agricultural University,Wuhan,430070,China 3.China State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,650223,China 4.Institute of Systems and Physical Biology,Shenzhen Bay Laboratory,Shenzhen,518132,China 5.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,518055,China 6.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine,Southern University of Science and Technology,Shenzhen,518055,China 7.Hubei Key Laboratory of Agricultural Bioinformatics,Huazhong Agricultural University,Wuhan,430070,China 8.Cancer Centre,Faculty of Health Sciences,University of Macau,Taipa,Macau,999078,China 9.Frontier Science Centre for Precision Oncology of Ministry of Education,University of Macau,Taipa,Macau,999078,China |
First Author Affilication | Department of Biology; School of Life Sciences |
Corresponding Author Affilication | Department of Biology; School of Life Sciences |
First Author's First Affilication | Department of Biology; School of Life Sciences |
Recommended Citation GB/T 7714 |
Shi,Zhaoying,Xu,Jinsheng,Niu,Longjian,et al. Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis[J]. Cell Reports,2023,42(3).
|
APA |
Shi,Zhaoying.,Xu,Jinsheng.,Niu,Longjian.,Shen,Wei.,Yan,Shuting.,...&Hou,Chunhui.(2023).Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis.Cell Reports,42(3).
|
MLA |
Shi,Zhaoying,et al."Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis".Cell Reports 42.3(2023).
|
Files in This Item: | There are no files associated with this item. |
|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment