Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy

Zhang，Baozhen1,2; Pan，Hong1,2; Chen，Ze1; Yin，Ting1; Zheng，Mingbin1,3; Cai，Lintao1,2

2023-02-22

10.1126/sciadv.adc8978

Science advances   Impact Factor & Quartile

2375-2548

2375-2548

A wide array of biocompatible micro/nanorobots are designed for targeted drug delivery and precision therapy largely depending on their self-adaptive ability overcoming complex barriers in vivo. Here, we report a twin-bioengine yeast micro/nanorobot (TBY-robot) with self-propelling and self-adaptive capabilities that can autonomously navigate to inflamed sites for gastrointestinal inflammation therapy via enzyme-macrophage switching (EMS). Asymmetrical TBY-robots effectively penetrated the mucus barrier and notably enhanced their intestinal retention using a dual enzyme-driven engine toward enteral glucose gradient. Thereafter, the TBY-robot was transferred to Peyer's patch, where the enzyme-driven engine switched in situ to macrophage bioengine and was subsequently relayed to inflamed sites along a chemokine gradient. Encouragingly, EMS-based delivery increased drug accumulation at the diseased site by approximately 1000-fold, markedly attenuating inflammation and ameliorating disease pathology in mouse models of colitis and gastric ulcers. These self-adaptive TBY-robots represent a safe and promising strategy for the precision treatment of gastrointestinal inflammation and other inflammatory diseases.

SCI

English

Others

National Natural Science Foundation of China[81971749] ; National Key Research and Development Program of China["2019YFE0198700","2022YFC2402400"] ; Guangdong Provincial Key Area RD Program[2020B1111540001] ; Natural Science Foundation of Guangdong Province[2022A1515010780] ; Shenzhen Science and Technology Program["JCYJ20200109114616534","JCYJ20210324101807020"]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000948176900012

AMER ASSOC ADVANCEMENT SCIENCE

2-s2.0-85148550246

Scopus

1.Guangdong Key Laboratory of Nanomedicine,CAS-HK Joint Lab of Biomaterials,Shenzhen Institute of Advanced Technology (SIAT),Chinese Academy of Sciences (CAS),Shenzhen,518055,China
2.University of Chinese Academy of Sciences,100049,China
3.National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Second Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518112,China

Zhang，Baozhen,Pan，Hong,Chen，Ze,et al. Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy[J]. Science advances,2023,9(8).

Zhang，Baozhen,Pan，Hong,Chen，Ze,Yin，Ting,Zheng，Mingbin,&Cai，Lintao.(2023).Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy.Science advances,9(8).

Zhang，Baozhen,et al."Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy".Science advances 9.8(2023).