| Title | Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade |
| Author | |
| Corresponding Author | Maheswaran，Shyamala |
| Joint first author | Fox，Douglas B.; Ebright，Richard Y.; Hong，Xin |
| Publication Years | 2023-12-01
|
| DOI | |
| Source Title | |
| EISSN | 2397-768X
|
| Volume | 7Issue:1 |
| Abstract | Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterization using mouse melanoma models, we show that the KEAP1/NRF2 pathway modulates sensitivity to ICB, independently of tumorigenesis. The NRF2 negative regulator, KEAP1, shows intrinsic variation in expression, leading to tumor heterogeneity and subclonal resistance. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | 共同第一
; Others
|
| Scopus EID | 2-s2.0-85149593434
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/497511 |
| Department | Department of Biochemistry 南方科技大学医学院 |
| Affiliation | 1.Massachusetts General Hospital Cancer Center and Harvard Medical School,Boston,02114,United States 2.Broad Institute of Harvard and MIT,Cambridge,02139,United States 3.Center for Engineering in Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States 4.Shriners Hospitals for Children,Boston,02114,United States 5.Department of Surgery,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States 6.Department of Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States 7.Howard Hughes Medical Institute,Bethesda,20815,United States 8.Department of Biochemistry,School of Medicine and Key University Laboratory of Metabolism and Health of Guangdong,Southern University of Science and Technology,Shenzhen,518055,China 9.Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou,311121,China |
| Recommended Citation GB/T 7714 |
Fox，Douglas B.,Ebright，Richard Y.,Hong，Xin,et al. Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade[J]. npj Precision Oncology,2023,7(1).
|
| APA |
Fox，Douglas B..,Ebright，Richard Y..,Hong，Xin.,Russell，Hunter C..,Guo，Hongshan.,...&Maheswaran，Shyamala.(2023).Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade.npj Precision Oncology,7(1).
|
| MLA |
Fox，Douglas B.,et al."Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade".npj Precision Oncology 7.1(2023).
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| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| s41698-023-00362-3.p（1310KB） | Open Access | -- | View | |||
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