| Title | Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease |
| Author | |
| Corresponding Author | Sun, Jichao; Wang, Jigang; Yang, Chuanbin |
| Publication Years | 2022-12-01
|
| DOI | |
| Source Title | |
| ISSN | 2152-5250
|
| Abstract | A key pathological feature of neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of aggregated and misfolded protein aggregates with limited effective therapeutic agents. TFEB (transcription factor EB), a key regulator of lysosomal biogenesis and autophagy, plays a pivotal role in the degradation of protein aggregates and has thus been regarded as a promising therapeutic target for these NDs. Here, we systematically summarize the molecular mechanisms and function of TFEB regulation. We then discuss the roles of TFEB and autophagy-lysosome pathways in major neurodegenerative diseases including AD and PD. Finally, we illustrate small molecule TFEB activators with protective roles in NDs animal models, which show great potential for being further developed into novel antineurodegenerative agents. Overall, targeting TFEB for enhancing lysosomal biogenesis and autophagy may represent a promising opportunity for the discovery of disease-modifying therapeutics for neurodegenerative disorders though more in-depth basic and clinical studies are required in the future. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China["82003721","81902787","82071193","32000673"]
; National Key Research and Development Program of China[2020YFA0908000]
; Shenzhen Science and Technology Innovation Commission["JCYJ20210324114014039","JCYJ2021032 4115800001","RCYX20210706092040044"]
; China Postdoctoral Science Foundation[2020M683182]
; Guangdong Basic and Applied Basic Research Foundation[2020A1515110549]
|
| WOS Research Area | Geriatrics & Gerontology
|
| WOS Subject | Geriatrics & Gerontology
|
| WOS Accession No | WOS:000938194300001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/501427 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Peoples R China 2.Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen, Peoples R China 3.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China 5.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hepatobiliary Surg, Div Life Sci & Med,Anhui Prov Key Lab Hepatopancre, Hefei, Peoples R China 6.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China 7.China Acad Chinese Med Sci, Inst Chinese Mat Med, Artemisinin Res Ctr, Beijing, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Yang, Jing,Zhang, Wei,Zhang, Shugeng,et al. Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease[J]. Aging and Disease,2022.
|
| APA |
Yang, Jing.,Zhang, Wei.,Zhang, Shugeng.,Iyaswamy, Ashok.,Sun, Jichao.,...&Yang, Chuanbin.(2022).Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease.Aging and Disease.
|
| MLA |
Yang, Jing,et al."Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer?s Disease and Parkinson?s Disease".Aging and Disease (2022).
|
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