2D Magnetic Microswimmers for Targeted Cell Transport and 3D Cell Culture Structure Construction

Chen, Zhi1; Song, Xiaoxia1; Mu, Xueliang1; Zhang, Junkai1; Cheang, U. Kei1,2,3

2023-02-01

10.1021/acsami.2c18955

ACS Applied Materials & Interfaces   Impact Factor & Quartile

1944-8244

1944-8252

Cell delivery using magnetic microswimmers is a promising tool for targeted therapy. However, it remains challenging to rapidly and uniformly manufacture cell-loaded microswimmers that can be assembled into cell-supporting structures at diseased sites. Here, rapid and uniform manufactur-able 2D magnetic achiral microswimmers with pores were fabricated to deliver bone marrow mesenchymal stem cells (BMSCs) to regenerate articular-damaged cartilage. Under actuation with magnetic fields, the BMSC-loaded microswimmers take advantage of the achiral structure to exhibit rolling or swimming motions to travel on smooth and rough surfaces, up inclined planes, or in the bulk fluid. Cell viability, proliferation, and differentiation tests performed days after cell seeding verified the microswimmers' biocompatibility. Long-distance targeting and in situ assemblies into 3D cell-supporting structures with BMSC-loaded microswimmers were demonstrated using a knee model and U-shaped wells. Overall, combining the advantages of preparing an achiral 2D structured microswimmer with magnetically driven motility results in a platform for cell transport and constructing 3D cell cultures that can improve cell delivery at lesion sites for biomedical applications.

2D microswimmers achiral microswimmers microrobots magnetic actuation cell delivery 3D cell culture structure

SCI

English

First ; Corresponding

Department of Science and Technology of Guangdong[2023A1515012229] ; Department of Education of Guangdong[2021ZDZX2037] ; Scienceand Technology Innovation Committee Foundation of Shenzhen["20200925155648005","RCYX20210609103644015","ZDSYS20200811143601004"] ; Shenzhen municipal government (Peacock Plan)[20181119590C]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000929870000001

AMER CHEMICAL SOC

Web of Science

1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Key Lab Biomimet Robot & Intelligent Syst, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Human Augmentat & Rehabil R, Shenzhen 518055, Peoples R China

Chen, Zhi,Song, Xiaoxia,Mu, Xueliang,et al. 2D Magnetic Microswimmers for Targeted Cell Transport and 3D Cell Culture Structure Construction[J]. ACS Applied Materials & Interfaces,2023.

Chen, Zhi,Song, Xiaoxia,Mu, Xueliang,Zhang, Junkai,&Cheang, U. Kei.(2023).2D Magnetic Microswimmers for Targeted Cell Transport and 3D Cell Culture Structure Construction.ACS Applied Materials & Interfaces.

Chen, Zhi,et al."2D Magnetic Microswimmers for Targeted Cell Transport and 3D Cell Culture Structure Construction".ACS Applied Materials & Interfaces (2023).