Air pollution exposure and vascular endothelial function: a systematic review and meta-analysis

Li, Jinyue1; Liu, Fangchao1; Liang, Fengchao1,2; Yang, Yuxin1; Lu, Xiangfeng1; Gu, Dongfeng1,2,3

2023

10.1007/s11356-023-25156-9

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH   Impact Factor & Quartile

0944-1344

1614-7499

Vascular endothelial dysfunction is an early stage to cardiovascular diseases (CVDs), but whether air pollution exposure has an effect on it remains unknown. We conducted a systematic review and meta-analysis to summarize epidemiological evidence between air pollution and endothelial dysfunction. We searched the database of PubMed, EMBASE, the Cochrane Library, and Web of Science up to November 10, 2022. Fixed and random effect models were used to pool the effect change or percent change (% change) and 95% confidence interval (95% CI) of vascular function associated with particulate matter (PM) and gaseous pollutants. I-2 statistics, funnel plot, and Egger's test were used to evaluate heterogeneity and publication bias. There were 34 articles included in systematic review, and 25 studies included in meta-analysis. For each 10 mu g/m(3) increment in short-term PM2.5 exposure, augmentation index (AIx) and pulse wave velocity (PWV) increased by 2.73% (95% CI: 1.89%, 3.57%) and 0.56% (95% CI: 0.22%, 0.89%), and flow-mediated dilation (FMD) decreased by 0.17% (95% CI: - 0.33%, - 0.00%). For each 10 mu g/m(3) increment in long-term PM2.5 exposure, FMD decreased by 0.99% (95% CI: - 1.41%, - 0.57%). The associations between remaining pollutants and outcomes were not statistically significant. The effect of short-term PM2.5 exposure on FMD change was stronger in population with younger age, lower female proportion, higher mean body mass index and higher PM2.5 exposure. Cardiac or vasoactive medication might attenuate this effect. Our study provides evidence that PM2.5 exposure had adverse impact on vascular endothelial function, indicating the importance of air quality improvement for early CVD prevention.

Air pollution Particulate matter Endothelial function Vascular function Systematic review Meta-analysis

SCI

English

Corresponding

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences["2021-I2M-1-010","2017-I2M-1-004"] ; National Key Ramp;D Program of China["2017YFC0211703","2018YFE0115300"] ; National Natural Science Foundation of China["91643208","82073658"]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000922951500001

SPRINGER HEIDELBERG

ENVIRONMENT/ECOLOGY

Web of Science

1.Chinese Acad Med Sci & Peking Union Med Coll, Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis,Dept Epidemiol,Key Lab Car, Beijing 10037, Peoples R China
2.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China

Li, Jinyue,Liu, Fangchao,Liang, Fengchao,et al. Air pollution exposure and vascular endothelial function: a systematic review and meta-analysis[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2023.

Li, Jinyue,Liu, Fangchao,Liang, Fengchao,Yang, Yuxin,Lu, Xiangfeng,&Gu, Dongfeng.(2023).Air pollution exposure and vascular endothelial function: a systematic review and meta-analysis.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH.

Li, Jinyue,et al."Air pollution exposure and vascular endothelial function: a systematic review and meta-analysis".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023).