| Title | Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery |
| Author | |
| Corresponding Author | Zeng, Chen; Wang, Peng George |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| EISSN | 1999-4923
|
| Volume | 15Issue:2 |
| Abstract | Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the success of COVID-19 mRNA vaccines. Ionizable cationic lipids are the most important component in LNPs. Herein, we developed a series of new ionizable lipids featuring bioreducible disulfide bonds, and constructed a library of lipids derived from dimercaprol. LNPs prepared from these ionizable lipids could be stored at 4 degrees C for a long term and are non-toxic toward HepG2 and 293T cells. In vivo experiments demonstrated that the best C4S18A formulations, which embody linoleoyl tails, show strong firefly luciferase (Fluc) mRNA expression in the liver and spleen via intravenous (IV) injection, or at the local injection site via intramuscular injection (IM). The newly designed ionizable lipids can be potentially safe and high-efficiency nanomaterials for mRNA therapy. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Shenzhen Science and Technology Program[KQTD20200909113758004]
; Natural Science Foundation of China[22107044]
; China Postdoctoral Science Foundation[2021M691436]
|
| WOS Research Area | Pharmacology & Pharmacy
|
| WOS Subject | Pharmacology & Pharmacy
|
| WOS Accession No | WOS:000940890200001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/501469 |
| Department | Department of Pharmacology 南方科技大学医学院 |
| Affiliation | Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Shenzhen 518055, Peoples R China |
| First Author Affilication | Department of Pharmacology; School of Medicine |
| Corresponding Author Affilication | Department of Pharmacology; School of Medicine |
| First Author's First Affilication | Department of Pharmacology; School of Medicine |
| Recommended Citation GB/T 7714 |
Shen, Zhigao,Liu, Cong,Wang, Ziqian,et al. Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery[J]. PHARMACEUTICS,2023,15(2).
|
| APA |
Shen, Zhigao.,Liu, Cong.,Wang, Ziqian.,Xie, Fengfei.,Liu, Xingwu.,...&Wang, Peng George.(2023).Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery.PHARMACEUTICS,15(2).
|
| MLA |
Shen, Zhigao,et al."Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery".PHARMACEUTICS 15.2(2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
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