| Title | A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics |
| Author | |
| Corresponding Author | Li, Yuanyuan; Duo, Yanhong; Tang, Ben Zhong |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 2050-750X
|
| EISSN | 2050-7518
|
| Abstract | The pursuit of phototheranostic agents with near-infrared II (NIR-II) emission, high photothermal conversion efficiency (PCE) and the robust generation of reactive oxygen species (ROS) in the aggregated state is always in high demand but remains a big challenge. Herein, we report a simple strategy to endow molecules with NIR-II imaging and photothermal therapy (PTT)/photodynamic therapy (PDT) abilities by equipping NIR-II aggregation-induced emission luminogens (AIEgens) with the cationic trimethylammonium unit, named as TDTN+. The resultant TDTN+ species can self-assemble into nanoparticles, which exhibit a maximum emission at similar to 1052 nm, a high PCE (66.7%), type I and type II ROS generation and a mitochondria-targeting ability, simultaneously. The TDTN+ can realize brain imaging with bright fluorescence and an effective tumor killing effect. Overall, this work presents an innovative design strategy to develop multimodality phototheranostic agents. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Key Research and Development Program of China[2021YFC2600202]
; National Natural Science Foundation of China[32102642]
; Innovation and Technology Commission[ITC-CNERC14SC01]
; Research Grant Council of Hong Kong["16306620","16303221"]
|
| WOS Research Area | Materials Science
|
| WOS Subject | Materials Science, Biomaterials
|
| WOS Accession No | WOS:000940747100001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/501481 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Jilin Univ, Coll Vet Med, Key Lab Zoonosis Res, Minist Educ, Changchun, Peoples R China 2.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden 3.Zhejiang Univ, Coll Opt Sci & Engn, Int Res Ctr Adv Photon, State Key Lab Modern Opt Instrumentat,Ctr Opt & El, Hangzhou 310058, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast Surg, Wuhan 430030, Peoples R China 5.Flinders Univ S Australia, Inst Nanoscale Sci & Technol, Coll Sci & Engn, Adelaide, SA 5042, Australia 6.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China 7.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Radiat Oncol,Clin Med Coll, Shenzhen 518020, Guangdong, Peoples R China |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Li, Yuanyuan,He, Mubin,Liu, Zeming,et al. A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics[J]. Journal of Materials Chemistry B,2023.
|
| APA |
Li, Yuanyuan.,He, Mubin.,Liu, Zeming.,Chuah, Clarence.,Tang, Youhong.,...&Tang, Ben Zhong.(2023).A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics.Journal of Materials Chemistry B.
|
| MLA |
Li, Yuanyuan,et al."A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics".Journal of Materials Chemistry B (2023).
|
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