The Risk Factors for New-Onset Calf Muscle Venous Thrombosis after Hip Fracture Surgery

Zhuang, Qianzheng1,2,3; He, Qifei2; Aikebaier, Aobulikasimu2; Chen, Wenshi4; Liu, Jianquan1; Wang, Daping5

2023-02-01

10.3390/jpm13020257

JOURNAL OF PERSONALIZED MEDICINE   Impact Factor & Quartile

2075-4426

Background: Calf muscle venous thrombosis (CMVT) is among the most important medical complications after hip surgery. CMVT has been known for many years, but many opinions about the incidence and risk factors of CMVT are still controversial. The objective of this retrospective study was to investigate the incidence and associated risk factors of postoperative CMVT in patients with hip fractures. Methods: Patients with hip fractures from January 2020 to April 2022 (n = 320) at Shenzhen Second People's Hospital were recruited in this study. The personal characteristics and clinical data of CMVT and no-CMVT patients were compared and analyzed. Binary logistic regression analyses were performed to identify potential risk factors of CMVT in patients with hip fractures. Finally we performed a receiver operating characteristic (ROC) curve analysis to compare the diagnostic values of different variables. Results: The overall incidence of new-onset CMVT in patients with hip fractures was 18.75% (60 of 320). Among the 60 CMVT patients, 70% (42 of 60) were diagnosed with femoral neck fractures, 28.3% (17 of 60) with intertrochanteric fractures, and 1.7% (1 of 60) with subtrochanteric fractures. No pulmonary embolism (PE) occurred. High preoperative D-dimer (OR = 1.002, 95%CI 0.97-1.03), sex (OR = 1.22, 95%CI 0.51-2.96), the caprini score (OR = 2.32, 95%CI 1.05-5.16) and the waterlow score (OR = 1.077, 95%CI 0.35-3.36) significantly increased the risk of developing postoperative new-onset CMVT. Conclusions: CMVT has become a common clinical disease, and its harm should not be underestimated. Our study found that D-dimer, sex, the caprini score and the waterlow score were independent risk factors for postoperative CMVT. According to our clinical work, we should pay attention to identifying the risk factors of CMVT formation and targeted intervention measures to prevent new-onset CMVT.

hip fracture calf muscle venous thrombosis deep venous thrombosis

SCI

English

Corresponding

National Natural Science Foundation of China["81972085","82172465"] ; China University Industry-University-Research Innovation Fund[2021JH037] ; Guangdong Provincial Key Clinical Discipline-Orthopedics[2000005] ; Shenzhen Fund for Guangdong Provincial High level Clinical Key Specialties[SZGSP007] ; Sanming Project of Shenzhen Health and Family Planning Commission[SZSM201612086] ; Shenzhen Key Medical Discipline Construction Fund[SZXK025]

Health Care Sciences & Services ; General & Internal Medicine

Health Care Sciences & Services ; Medicine, General & Internal

WOS:000940377600001

MDPI

Web of Science

1.Shenzhen Univ, Hosp 1, Shenzhen Peoples Hosp 2, Hand & Foot Surg Dept, Shenzhen 518000, Peoples R China
2.Shenzhen Univ, Hosp 1, Shenzhen Peoples Hosp 2, Dept Bone Joint & Musculoskeletal Tumor, Shenzhen 518000, Peoples R China
3.Shantou Univ Med Coll, Shantou 515041, Peoples R China
4.Shenzhen Univ, Hosp 1, Shenzhen Peoples Hosp 2, Dept Rehabil, Shenzhen 518060, Peoples R China
5.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Zhuang, Qianzheng,He, Qifei,Aikebaier, Aobulikasimu,et al. The Risk Factors for New-Onset Calf Muscle Venous Thrombosis after Hip Fracture Surgery[J]. JOURNAL OF PERSONALIZED MEDICINE,2023,13(2).

Zhuang, Qianzheng,He, Qifei,Aikebaier, Aobulikasimu,Chen, Wenshi,Liu, Jianquan,&Wang, Daping.(2023).The Risk Factors for New-Onset Calf Muscle Venous Thrombosis after Hip Fracture Surgery.JOURNAL OF PERSONALIZED MEDICINE,13(2).

Zhuang, Qianzheng,et al."The Risk Factors for New-Onset Calf Muscle Venous Thrombosis after Hip Fracture Surgery".JOURNAL OF PERSONALIZED MEDICINE 13.2(2023).