The Role and Mechanism of Action of Mitophagy in Various Liver Diseases

Wang, Chunling1; Wang, Yijin1,2

2023-02-01

10.1089/ars.2022.0114

ANTIOXIDANTS & REDOX SIGNALING   Impact Factor & Quartile

1523-0864

1557-7716

Significance: Liver disease is one of the biggest threats to public health, affecting as much as 5.5 million people worldwide. Mitochondrial dysfunction is associated with various acute and chronic liver diseases. Mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role either in the pathogenesis or in maintaining hepatic homeostasis in response to various liver diseases.Recent Advances: Significant progress has been achieved to ascertain the causes of liver disease. The conserved pathways for mitochondrial degradation via mitophagy, the deregulation of mitophagy in liver diseases, and pharmacological or genetic maneuvers that alter the mitophagic flux for liver disease treatment have been widely studied but yet to be comprehensively reviewed.Critical Issues: Liver disease is considered a leading cause of mortality globally, causing the heavy burden of disability and the increased health care utilization that needs to be settled urgently. Mitophagy plays an important role in protecting liver from tissue damage to maintain hepatic homeostasis or in pathogenesis of liver disease. Elaborating mitophagy implicated in the pathogenesis of liver disease, as well as potential therapeutic regimens by targeting mitophagy is of great significance for the understanding and treatment of liver disease.Future Directions: This review comprehensively describes the distinct mitophagy signaling pathways and their interplay with various liver diseases. Given that mitophagy affects a wide array of physiological processes, a deeper understanding of how to modulate mitophagy could provide innovative avenues for precise therapy. Future studies based on pharmacologically or genetically targeting mitophagy-relevant factors will uncover the links between intact mitophagic responses and hepatic homeostasis in physiological and pathological settings. This will allow us to overcome obstacles of applying mitophagy as the therapeutic target in the clinic.

molecular mechanisms signaling pathway mitochondria liver disease mitophagy

SCI

English

First ; Corresponding

Educational Committee of Guangdong for specific program of key scientific research[2021ZDZX2016] ; Technology Innovation Committee of ShenZhen for fundamental research[JCYJ20210324103808023] ; China Postdoctoral Science Foundation[2021M701574]

Biochemistry & Molecular Biology ; Endocrinology & Metabolism

Biochemistry & Molecular Biology ; Endocrinology & Metabolism

WOS:000941522600001

MARY ANN LIEBERT, INC

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Guangdong, Peoples R China

Wang, Chunling,Wang, Yijin. The Role and Mechanism of Action of Mitophagy in Various Liver Diseases[J]. ANTIOXIDANTS & REDOX SIGNALING,2023.

Wang, Chunling,&Wang, Yijin.(2023).The Role and Mechanism of Action of Mitophagy in Various Liver Diseases.ANTIOXIDANTS & REDOX SIGNALING.

Wang, Chunling,et al."The Role and Mechanism of Action of Mitophagy in Various Liver Diseases".ANTIOXIDANTS & REDOX SIGNALING (2023).