Mn3O4 Nanoshell Coated Metal-Organic Frameworks with Microenvironment-Driven O-2 Production and GSH Exhaustion Ability for Enhanced Chemodynamic and Photodynamic Cancer Therapies

Li, Wenya1; Li, Rongtian2; Ye, Qiang1; Zou, Yiming3; Lu, Xing1; Zhang, Wenhua4; Chen, Jinxiang3; Zhao, Yinghua1

2023-02-01

10.1002/adhm.202202280

Advanced Healthcare Materials   Impact Factor & Quartile

2192-2640

2192-2659

Nanomedicine exhibits emerging potentials to deliver advanced therapeutic strategies in the fight against triple-negative breast cancer (TNBC). Nevertheless, it is still difficult to develop a precise codelivery system that integrates highly effective photosensitizers, low toxicity, and hydrophobicity. In this study, PCN-224 is selected as the carrier to enable effective cancer therapy through light-activated reactive oxygen species (ROS) formation, and the PCN-224@Mn3O4@HA is created in a simple one-step process by coating Mn3O4 nanoshells on the PCN-224 template, which can then be used as an "ROS activator" to exert catalase- and glutathione peroxidase-like activities to alleviate tumor hypoxia while reducing tumor reducibility, leading to improved photodynamic therapeutic (PDT) effect of PCN-224. Meanwhile, Mn2+ produced cytotoxic hydroxyl radicals (center dot OH) via the Fenton-like reaction, thus producing a promising spontaneous chemodynamic therapeutic (CDT) effect. Importantly, by remodeling the tumor microenvironment (TME), Mn3O4 nanoshells downregulated hypoxia-inducible factor 1 alpha expression, inhibiting tumor growth and preventing tumor revival. Thus, the developed nanoshells, via light-controlled ROS formation and multimodality imaging abilities, can effectively inhibit tumor proliferation through synergistic PDT/CDT, and prevent tumor resurgence by remodeling TME.

chemodynamic therapy metal-organic frameworks Mn3O4 nanoshells photodynamic therapy tumor microenvironment remodeling

SCI

English

Others

National Natural Science Foundation of China["81871510","82172014"] ; Natural Science Foundation of Guangdong Province[2023A030313574] ; National Key Research and Development Program of China[2017YFC1309100] ; Science and Technology Program of Guangzhou[201904010410]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000935059500001

WILEY

Web of Science

1.Southern Med Univ, Acad Orthoped, Dept Radiol, Affiliated Hosp 3, Guangzhou 510630, Peoples R China
2.Southern Univ Sci & Technol Hosp, Dept Clin Pharm, Shenzhen 51805, Peoples R China
3.Southern Med Univ, Sch Pharmaceut Sci, NMPA Key Lab Res & Evaluat Drug Metab, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China
4.Soochow Univ, Coll Chem, Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

Li, Wenya,Li, Rongtian,Ye, Qiang,et al. Mn3O4 Nanoshell Coated Metal-Organic Frameworks with Microenvironment-Driven O-2 Production and GSH Exhaustion Ability for Enhanced Chemodynamic and Photodynamic Cancer Therapies[J]. Advanced Healthcare Materials,2023.

Li, Wenya.,Li, Rongtian.,Ye, Qiang.,Zou, Yiming.,Lu, Xing.,...&Zhao, Yinghua.(2023).Mn3O4 Nanoshell Coated Metal-Organic Frameworks with Microenvironment-Driven O-2 Production and GSH Exhaustion Ability for Enhanced Chemodynamic and Photodynamic Cancer Therapies.Advanced Healthcare Materials.

Li, Wenya,et al."Mn3O4 Nanoshell Coated Metal-Organic Frameworks with Microenvironment-Driven O-2 Production and GSH Exhaustion Ability for Enhanced Chemodynamic and Photodynamic Cancer Therapies".Advanced Healthcare Materials (2023).