| Title | Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair |
| Author | |
| Corresponding Author | Ren, Fuzeng |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 2373-9878
|
| Abstract | Porous tantalum (Ta) is a potential bone substitute due to its excellent biocompatibility and desirable mechanical properties. In this work, a series of porous Ta materials with interconnected micropores and varying pore sizes from 23 to 210 mu m were fabricated using spark plasma sintering. The porous structure was formed by thermal decomposition of ammonium bicarbonate powder premixed in the Ta powder. The pore size and porosity were controlled by the categorized particle size of ammonium bicarbonate. The porous Ta has elastic moduli in the range of 2.1-3.2 GPa and compressive yield strength in the range of 23-34 MPa, which are close to those of human bone. In vitro, as-fabricated porous Ta demonstrates excellent biocompatibility by supporting adhesion and proliferation of preosteoblasts. In vivo studies also validate its bone repair capability after implantation in a rat femur defect model. The study demonstrates a facile strategy to fabricate porous Ta with controllable pore size for bone repair. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Natural Science Foundation of China[52122102]
; Basic and Applied Basic Research Fundation of Guangdong Province[2022B1515120082]
|
| WOS Research Area | Materials Science
|
| WOS Subject | Materials Science, Biomaterials
|
| WOS Accession No | WOS:000930704800001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/501531 |
| Department | Department of Materials Science and Engineering |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Kowloon, Hong Kong 999077, Peoples R China 3.Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Kowloon, Hong Kong 999077, Peoples R China |
| First Author Affilication | Department of Materials Science and Engineering |
| Corresponding Author Affilication | Department of Materials Science and Engineering |
| First Author's First Affilication | Department of Materials Science and Engineering |
| Recommended Citation GB/T 7714 |
Liang, Dingshan,Zhong, Chuanxin,Jiang, Feilong,et al. Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair[J]. ACS Biomaterials Science & Engineering,2023.
|
| APA |
Liang, Dingshan,Zhong, Chuanxin,Jiang, Feilong,Liao, Junchen,Ye, Haixia,&Ren, Fuzeng.(2023).Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair.ACS Biomaterials Science & Engineering.
|
| MLA |
Liang, Dingshan,et al."Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair".ACS Biomaterials Science & Engineering (2023).
|
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