中文版 | English
Title

Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy

Author
Corresponding AuthorZhang, Jianglin
Publication Years
2023-02-01
DOI
Source Title
EISSN
2366-3987
Abstract
Nanosheets exhibit highly specific recognition and can be effectively enriched in tumor cells. Controlling nanosheet size and reducing its potential toxicity are key issues in the photothermal therapy of tumors. Herein, a multifunctional nanoplatform based on molybdenum disulfide (MoS2) is developed using a green solvent with antitumor activity, ionic liquid (IL) exfoliation, and surface modification to prepare a few layers of IL-MoS2 nanosheets, with a lateral dimension of approximate to 96 nm and thickness of 4 nm. The PEG-b-PIL polymer improves the biocompatibility, physiological stability, and biodegradability of the nanosheet, and IL-MoS2-PEG-b-PIL exhibits good photothermal stability and photothermal effects. The in vitro and in vivo results show that IL-MoS2-PEG-b-PIL nanosheets synergistically inhibit tumor cell growth in combination with photothermal therapy and chemotherapy under 808 nm laser irradiation. The steady increase in the weight of mice during the treatment indicates that the nanosheets are safe. Therefore, the results confirm that IL-MoS2-PEG-b-PIL nanosheets exhibit good antitumor effects and provide a promising strategy for clinical cancer treatments.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
National Natural Science Foundation of China["82073018","21703218"] ; Shenzhen Science and Technology Innovation Committee["JCYJ20180507183907224","KQTD20170809110344233"] ; Economic, Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center[201901161514] ; Guangdong Province Covid-19 Pandemic Control Research Fund[2020KZDZX1220]
WOS Research Area
Pharmacology & Pharmacy
WOS Subject
Pharmacology & Pharmacy
WOS Accession No
WOS:000942675900001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/501539
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Dermatol, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
4.Peoples Hosp Geriatr Ctr, Dept Shenzhen, Shenzhen 518020, Guangdong, Peoples R China
5.Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
6.Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
7.Univ Idaho, Dept Chem, Moscow, ID 83844 USA
First Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Lu, Beibei,Hu, Shunyou,Wu, Chengyu,et al. Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy[J]. ADVANCED THERAPEUTICS,2023.
APA
Lu, Beibei,Hu, Shunyou,Wu, Chengyu,Zhang, Jichuan,Zhang, Jianglin,&Zhang, Jiaheng.(2023).Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy.ADVANCED THERAPEUTICS.
MLA
Lu, Beibei,et al."Functionalized Ionic Liquid Exfoliated MoS2 Nanosheets for Photoacoustic Imaging Guided Synergistic Photothermal/Chemotherapy".ADVANCED THERAPEUTICS (2023).
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