PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

Wang, Ziqi1; Liu, Bo1; Tu, Jingyao1; Xiang, Jingfeng2,3; Xiong, Hui4; Wu, Yue5; Ding, Shuaijie6,7; Zhu, Daoming2,3; Zhu, Dongyong8; Liu, Fei1; Hu, Guangyuan1; Yuan, Xianglin1

2023-02-01

10.3390/pharmaceutics15020487

PHARMACEUTICS   Impact Factor & Quartile

1999-4923

Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in combination with microwave (MW) hyperthermia for RT sensitization. SPH with stable properties was produced by combining SFN and PLGA in a specific ratio and encapsulating the mixture in agarose hydrogel. Intratumoral injection of SPH to mice combined with MW hyperthermia can not only directly cause thermal damage to tumor cells, but also increase blood oxygen delivery to the tumor site, thus overcoming the problem of intratumoral hypoxia and achieving "first layer" RT sensitization. Moreover, high temperatures can cause the hydrogel to disintegrate and release SFN. Not only can SFN inhibit tumor growth, but it can also achieve the "second layer" of RT sensitization by inhibiting glutathione (GSH) synthesis in cells and increasing reactive oxygen species (ROS) production. Experiments, both in vitro and in vivo, have indicated that SPH and MW hyperthermia can achieve a double RT sensitization effect and a significant tumor inhibition effect. In conclusion, combining our SPH nanosystem and thermoradiotherapy is a promising anti-tumor treatment.

sorafenib PLGA nanoparticles microwave hyperthermia radiotherapy breast cancer

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Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000941003600001

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1.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan 430030, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Urol, Wuhan 430030, Peoples R China
6.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg,Shenzhen Peoples Hosp,C, Shenzhen 518020, Peoples R China
7.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Geriat,Shenzhen Peoples Hosp,Clin Med Coll 2, Shenzhen 518020, Peoples R China
8.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China

Wang, Ziqi,Liu, Bo,Tu, Jingyao,et al. PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy[J]. PHARMACEUTICS,2023,15(2).

Wang, Ziqi.,Liu, Bo.,Tu, Jingyao.,Xiang, Jingfeng.,Xiong, Hui.,...&Yuan, Xianglin.(2023).PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy.PHARMACEUTICS,15(2).

Wang, Ziqi,et al."PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy".PHARMACEUTICS 15.2(2023).