中文版 | English
Title

Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA

Author
Corresponding AuthorLi, Haibo; Ye, Wencai; Wang, Lei; Huang, Wei
Publication Years
2023-04-01
DOI
Source Title
ISSN
0006-2952
EISSN
1873-2968
Volume210
Abstract
The epidemic of methicillin-resistant Staphylococcus aureus (MRSA) infections has created a critical health threat. The drug resistance of MRSA makes the development of drugs with new modes of action particularly urgent. In this study, we found that a natural product derivative pyrimirhodomyrtone (PRM) exerted antibacterial activity against S. aureus, including MRSA, both in vitro and in vivo. Genetic and biochemical studies revealed the interaction between PRM and N-acetylglucosamine-6-phosphate deacetylase (NagA) and the inhibitory effect of PRM on its deacetylation activity. We also found that PRM causes depolarization and destroys the integrity of the cell membrane. The elucidation of the antibacterial mechanism will inspire the subsequent development of new anti-MRSA drugs based on PRM.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China[82173859]
WOS Research Area
Pharmacology & Pharmacy
WOS Subject
Pharmacology & Pharmacy
WOS Accession No
WOS:000942959900001
Publisher
ESI Research Field
PHARMACOLOGY & TOXICOLOGY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/502138
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Coll Pharm, Ctr Bioact Nat Mol & Innovat Drugs Res, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 511443, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Shenzhen Inst Re, Shenzhen 518020, Peoples R China
3.Third Mil Med Univ, Coll Pharm, Natl Engn Res Ctr Immunol Prod, Dept Microbiol & Biochem Pharm, Chongqing 400038, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Clin Microb, Shenzhen 518020, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Zeng, Huan,Cheng, Minjing,Liu, Jingyi,et al. Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA[J]. BIOCHEMICAL PHARMACOLOGY,2023,210.
APA
Zeng, Huan.,Cheng, Minjing.,Liu, Jingyi.,Hu, Chunxia.,Lin, Shilin.,...&Huang, Wei.(2023).Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA.BIOCHEMICAL PHARMACOLOGY,210.
MLA
Zeng, Huan,et al."Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA".BIOCHEMICAL PHARMACOLOGY 210(2023).
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