| Title | Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA |
| Author | |
| Corresponding Author | Li, Haibo; Ye, Wencai; Wang, Lei; Huang, Wei |
| Publication Years | 2023-04-01
|
| DOI | |
| Source Title | |
| ISSN | 0006-2952
|
| EISSN | 1873-2968
|
| Volume | 210 |
| Abstract | The epidemic of methicillin-resistant Staphylococcus aureus (MRSA) infections has created a critical health threat. The drug resistance of MRSA makes the development of drugs with new modes of action particularly urgent. In this study, we found that a natural product derivative pyrimirhodomyrtone (PRM) exerted antibacterial activity against S. aureus, including MRSA, both in vitro and in vivo. Genetic and biochemical studies revealed the interaction between PRM and N-acetylglucosamine-6-phosphate deacetylase (NagA) and the inhibitory effect of PRM on its deacetylation activity. We also found that PRM causes depolarization and destroys the integrity of the cell membrane. The elucidation of the antibacterial mechanism will inspire the subsequent development of new anti-MRSA drugs based on PRM. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China[82173859]
|
| WOS Research Area | Pharmacology & Pharmacy
|
| WOS Subject | Pharmacology & Pharmacy
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| WOS Accession No | WOS:000942959900001
|
| Publisher | |
| ESI Research Field | PHARMACOLOGY & TOXICOLOGY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/502138 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Jinan Univ, Coll Pharm, Ctr Bioact Nat Mol & Innovat Drugs Res, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 511443, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Shenzhen Inst Re, Shenzhen 518020, Peoples R China 3.Third Mil Med Univ, Coll Pharm, Natl Engn Res Ctr Immunol Prod, Dept Microbiol & Biochem Pharm, Chongqing 400038, Peoples R China 4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Clin Microb, Shenzhen 518020, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Zeng, Huan,Cheng, Minjing,Liu, Jingyi,et al. Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA[J]. BIOCHEMICAL PHARMACOLOGY,2023,210.
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| APA |
Zeng, Huan.,Cheng, Minjing.,Liu, Jingyi.,Hu, Chunxia.,Lin, Shilin.,...&Huang, Wei.(2023).Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA.BIOCHEMICAL PHARMACOLOGY,210.
|
| MLA |
Zeng, Huan,et al."Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA".BIOCHEMICAL PHARMACOLOGY 210(2023).
|
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