南方科技大学知识苑(SUSTech KC): Synthesis of Tetracyclic Core Structure of Daphnezomines A and B

Title	Synthesis of Tetracyclic Core Structure of Daphnezomines A and B
Author	Hu Jingping1,2,3 ; Chen Wenqing2,3 ; Jiang Yuyang2,3 ; Xu Jing2,3,4
Corresponding Author	Xu Jing
Publication Years	2023
DOI	10.6023/cjoc202208014
Source Title	CHINESE JOURNAL OF ORGANIC CHEMISTRY Impact Factor & Quartile
ISSN	0253-2786
Volume	43 Issue:1
Abstract	Among the tiniest Daphniphyllum alkaloid subfamilies, daphnezomine A-type alkaloids consist of only three known members, namely daphnezomine A (1), daphnezomine B (2) and dapholdhamine B. These alkaloids contain a unique aza-adamantane core along with nine contiguous stereogenic centers, thus presenting remarkable synthetic challenges. The synthesis of tetracyclic core structure of 1 and 2 was reported. The key steps in our approach include a Huang's amide-activa tion-annulation and a Hutchins-Kabalka reductive rearrangement.
Keywords	total synthesis Daphniphyllum alkaloids daphnezomine A daphnezomine B aza-adamantane Huang's amide-activation-annulation Hutchins-Kabalka reductive rearrangement
URL	[Source Record]
Indexed By	SCI
Language	Chinese
SUSTech Authorship	Corresponding
Funding Project	National Natural Science Foundation of China[21971104] ; Key Research Projects in Colleges and Universities of Education Department of Guangdong Province[2021ZDZX2035] ; Shenzhen Bay Laboratory[SZBL2019062801006] ; Shenzhen Nobel Prize Scientists Laboratory Project[C17783101] ; Guangdong Innovative Program[2019BT02Y335] ; Innovative Team of Universities in Guangdong Province[2020KCXTD016] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Shenzhen Science and Technology Innovation Committee[ZDSYS20190902093215877]
WOS Research Area	Chemistry
WOS Subject	Chemistry, Organic
WOS Accession No	WOS:000933120300011
Publisher	SCIENCE PRESS
ESI Research Field	CHEMISTRY
Data Source	Web of Science
Citation statistics	Cited Times [WOS]:2
Document Type	Journal Article
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/502140
Department	Department of Chemistry 深圳格拉布斯研究院
Affiliation	1.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen Key Lab Small Mol Drug Discovery & Synth, Shenzhen 518055, Guangdong, Peoples R China 4.Shenzhen Bay Lab, Shenzhen 518132, Guangdong, Peoples R China
First Author Affilication	Department of Chemistry; Shenzhen Grubbs Institute
Corresponding Author Affilication	Department of Chemistry; Shenzhen Grubbs Institute
Recommended Citation GB/T 7714	Hu Jingping,Chen Wenqing,Jiang Yuyang,et al. Synthesis of Tetracyclic Core Structure of Daphnezomines A and B[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2023,43(1).
APA	Hu Jingping,Chen Wenqing,Jiang Yuyang,&Xu Jing.(2023).Synthesis of Tetracyclic Core Structure of Daphnezomines A and B.CHINESE JOURNAL OF ORGANIC CHEMISTRY,43(1).
MLA	Hu Jingping,et al."Synthesis of Tetracyclic Core Structure of Daphnezomines A and B".CHINESE JOURNAL OF ORGANIC CHEMISTRY 43.1(2023).

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