中文版 | English
Title

Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center

Author
Corresponding AuthorXiong, Zibo
Publication Years
2023-02-01
DOI
Source Title
ISSN
0894-0959
EISSN
1525-139X
Abstract
IntroductionRecent studies report that latent tuberculosis infection (LTBI) may lead to an increased risk of cardiovascular disease (CVD) that led us to hypothesize that LTBI may play an important role in major adverse cardiovascular events (MACE) in dialysis patients. MethodsA single-center retrospective cohort study was conducted. A total of 270 patients undergoing hemodialysis or peritoneal dialysis more than 3 months were included. The interferon enzyme-linked immunospot (IFN-gamma ELISPOT) assay was used for the diagnosis of LTBI. Primary endpoints were MACE, including all-cause death and acute coronary syndrome (ACS). The association between LTBI and MACE was examined using multivariate Cox proportional hazards regression after adjusting for covariates and Kaplan-Meier survival analysis. ResultsIn our study, the patients were classified into LTBI (n = 47) or non-LTBI (n = 223) groups. Independent risk factors for LTBI in dialysis population were prior tuberculosis (TB) history (odds ratio [OR] 4.817 [1.064-22.306]), tobacco use (OR 2.903 [1.155-7.299]), and older age (OR 1.027 [1.002-1.053]). After a median follow-up of 39 months, the incidence of active TB was 6.4% versus 0% in dialysis patients with and without LTBI, respectively (p = 0.005). Multivariate Cox analysis showed that LTBI was significantly associated with MACE (hazard ratio [HR] 2.540 [1.490-4.350]) after adjustment for potential confounders. ConclusionsPrior TB history, tobacco use, and the elderly can be used to select cost-effective LTBI screening target groups in dialysis patients. LTBI is not only closely related to active TB but also an independent risk factor for higher incidence of MACE in dialysis population.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
WOS Research Area
Urology & Nephrology
WOS Subject
Urology & Nephrology
WOS Accession No
WOS:000937404300001
Publisher
ESI Research Field
CLINICAL MEDICINE
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/502142
DepartmentDepartment of Statistics and Data Science
Affiliation
1.Peking Univ, Renal Div, Shenzhen Hosp, Shenzhen, Peoples R China
2.Shenzhen Luohu Dist Tradit Chinese Med Hosp, Renal Div, Shenzhen, Peoples R China
3.Sun Yat sen Univ, Affiliated Hosp 8, Renal Div, Shenzhen, Peoples R China
4.Affiliated Shenzhen Third Hosp, Guangdong Key Lab Diag & Treatment Emerging Infect, Shenzhen, Peoples R China
5.Southern Univ Sci & Technol, Dept Stat & Data Sci, Shenzhen, Peoples R China
6.Peking Univ, Renal Div, Shenzhen Hosp, Lianhua Rd 1120, Shenzhen 518036, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Xia, Yun,Fan, Qiuxia,Zhang, Jieyun,et al. Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center[J]. SEMINARS IN DIALYSIS,2023.
APA
Xia, Yun.,Fan, Qiuxia.,Zhang, Jieyun.,Jiang, Li.,Huang, Xiaoyan.,...&Xiong, Zibo.(2023).Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center.SEMINARS IN DIALYSIS.
MLA
Xia, Yun,et al."Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center".SEMINARS IN DIALYSIS (2023).
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