中文版 | English
Title

Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma

Author
Corresponding AuthorZhang, Peng; Zhang, Xiangmin; Zeng, Xianhai
Publication Years
2022-12-22
DOI
Source Title
EISSN
2296-889X
Volume9
Abstract
Transient receptor potential vanilloid type 4 (TRPV4) can function as an oncogene or tumor suppressor depending on the tumor types. However, little is known regarding the effect of TRPV4 in nasopharyngeal carcinoma (NPC), a highly prevalent malignancy in Southern China and Southeast Asia. We found that TRPV4 mRNA and protein levels were significantly upregulated in NPC tissues. In addition, activation of TRPV4 in NPC cell lines using GSK1016790A (100 nM) induced a Ca2+ influx, whereas pharmacological inhibition or gene knockdown of TRPV4 reduced the proliferation rates of NPC cells. TRPV4 knockdown also decreased the growth of tumor xenografts in vivo. Mechanistically, TRPV4-mediated tumorigenesis is dependent on the activation of Ca2+/calcineurin/calcineurin-nuclear factor of activated T cell 4 (NFAT4) signaling. Furthermore, NFAT4 protein level was overexpressed in NPC tissues and correlated positively with TRPV4. Taken together, TRPV4 promotes the malignant potential of NPC cells by activating NFAT4 signaling. Our findings highlight TRPV4-NFAT4 axis as a potential therapeutic target in NPC.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
WOS Research Area
Biochemistry & Molecular Biology
WOS Subject
Biochemistry & Molecular Biology
WOS Accession No
WOS:000944040200001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/502144
DepartmentSchool of Medicine
Affiliation
1.Longgang Otorhinolaryngol Hosp, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Inst Otorhinolaryngol, Shenzhen Key Lab Otorhinolaryngol, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China
4.Shenzhen Middle Sch, Shenzhen, Guangdong, Peoples R China
5.Chinese Univ Hong Kong, Dept Otorhinolaryngol Head & Neck Surg, Hong Kong, Peoples R China
6.Huzhou Univ, Sch Med & Nursing, Huzhou, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Peng,Li, Ke,Wang, Zhen,et al. Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9.
APA
Zhang, Peng.,Li, Ke.,Wang, Zhen.,Wu, Yongjin.,Zhang, Hua.,...&Zeng, Xianhai.(2022).Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma.FRONTIERS IN MOLECULAR BIOSCIENCES,9.
MLA
Zhang, Peng,et al."Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Zhang, Peng]'s Articles
[Li, Ke]'s Articles
[Wang, Zhen]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Zhang, Peng]'s Articles
[Li, Ke]'s Articles
[Wang, Zhen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Peng]'s Articles
[Li, Ke]'s Articles
[Wang, Zhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.