| Title | NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy |
| Author | |
| Corresponding Author | Zhang, Xuanjun; Tian, Leilei |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 1944-8244
|
| EISSN | 1944-8252
|
| Abstract | mediated Fenton reaction can amplify intracellular oxidative stress by producing toxic center dot OH. However, the high-dose need for Fe2+ delivery in tumors and its significant cytotoxicity to normal tissues set a challenge. Therefore, a controllable delivery to activate the Fenton reaction and enhance Fe2+ tumor accumulation has become an approach to solve this conflict. Herein, we report a rare-earthtechniques and DNA nanotechnology to realize programmable Fe2+ delivery. Ferrocenes, the source of Fe2+, are modified on the surface of RENCs through pH-responsive DNAs, which are further shielded by a PEG layer to elongate blood circulation and "turn off" the cytotoxicity of ferrocene. The up-/down-conversion dual-mode emissions of RENCs endow the delivery system with both capabilities of diagnosis and delivery control. The down-conversion NIR-II fluorescence can locate tumors. Consequently, upconversion UV light spatiotemporally activates the catalytic activity of Fe2+ by shedding off the protective PEG layer. The exposed ferrocene-DNAs not only can "turn on" Fenton catalytic activity but also respond to tumor acidity, driving cross-linking and enhanced Fe2+ enrichment in tumors by 4.5-fold. Accordingly, this novel design concept will be inspiring for developing CDT nanomedicines in the future. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China[51973089]
; Shenzhen Science and Technology Innovation Commission[KQTD20170810111314625]
|
| WOS Research Area | Science & Technology - Other Topics
; Materials Science
|
| WOS Subject | Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
|
| WOS Accession No | WOS:000935096400001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/513398 |
| Department | Department of Materials Science and Engineering |
| Affiliation | 1.Univ Macau, Fac Hlth Sci, Taipa 999078, Macau, Peoples R China 2.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China |
| Corresponding Author Affilication | Department of Materials Science and Engineering |
| Recommended Citation GB/T 7714 |
Wei, Zixiang,Chao, Zhicong,Zhang, Xindan,et al. NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy[J]. ACS Applied Materials & Interfaces,2023.
|
| APA |
Wei, Zixiang.,Chao, Zhicong.,Zhang, Xindan.,Yu, Jiantao.,Xiao, Fan.,...&Tian, Leilei.(2023).NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy.ACS Applied Materials & Interfaces.
|
| MLA |
Wei, Zixiang,et al."NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy".ACS Applied Materials & Interfaces (2023).
|
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