Title | Applications and prospects of cryo-EM in drug discovery |
Author | |
Corresponding Author | Wang, Da-Ping; Zhang, Hua-Wei |
Publication Years | 2023-03-06
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DOI | |
Source Title | |
ISSN | 2095-7467
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EISSN | 2054-9369
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Volume | 10Issue:1 |
Abstract | Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology has been demonstrated as a powerful tool to accelerate drug development. Among different techniques, cryo-electron microscopy (cryo-EM) is emerging as the mainstream of structure determination of biomacromolecules in the past decade and has received increasing attention from the pharmaceutical industry. Although cryo-EM still has limitations in resolution, speed and throughput, a growing number of innovative drugs are being developed with the help of cryo-EM. Here, we aim to provide an overview of how cryo-EM techniques are applied to facilitate drug discovery. The development and typical workflow of cryo-EM technique will be briefly introduced, followed by its specific applications in structure-based drug design, fragment-based drug discovery, proteolysis targeting chimeras, antibody drug development and drug repurposing. Besides cryo-EM, drug discovery innovation usually involves other state-of-the-art techniques such as artificial intelligence (AI), which is increasingly active in diverse areas. The combination of cryo-EM and AI provides an opportunity to minimize limitations of cryo-EM such as automation, throughput and interpretation of medium-resolution maps, and tends to be the new direction of future development of cryo-EM. The rapid development of cryo-EM will make it as an indispensable part of modern drug discovery. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | First
; Corresponding
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WOS Research Area | General & Internal Medicine
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WOS Subject | Medicine, General & Internal
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WOS Accession No | WOS:000943371600001
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Publisher | |
Scopus EID | 2-s2.0-85149589873
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/513438 |
Department | Department of Biomedical Engineering |
Affiliation | 1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China 3.St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA 4.Chinese Univ Hong Kong, Fac Sci, Ctr Prot Sci & Crystallog, Sch Life Sci, Hong Kong 999077, Peoples R China 5.Chinese Acad Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol, Interdisciplinary Ctr Brain Informat, Shenzhen 518055, Guangdong, Peoples R China 6.Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Life & Hlth Sci, Shenzhen 518055, Guangdong, Peoples R China 7.Shenzhen Fundamental Res Inst, Shenzhen Hong Kong Inst Brain Sci, Shenzhen 518055, Guangdong, Peoples R China 8.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China 9.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Peoples R China 10.Southern Univ Sci & Technol, Cryo EM Facil Ctr, Shenzhen 518055, Guangdong, Peoples R China 11.Shenzhen Univ, Guangdong Prov Res Ctr Artificial Intelligence & D, Shenzhen Intelligent Orthopaed & Biomed Innovat Pl, Dept Orthoped,Shenzhen Peoples Hosp 2,Affiliated H, Shenzhen 518000, Guangdong, Peoples R China 12.Southern Univ Sci & Technol, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China |
First Author Affilication | Department of Biomedical Engineering |
Corresponding Author Affilication | Department of Biomedical Engineering; Southern University of Science and Technology |
First Author's First Affilication | Department of Biomedical Engineering |
Recommended Citation GB/T 7714 |
Zhu, Kong-Fu,Yuan, Chuang,Du, Yong-Ming,et al. Applications and prospects of cryo-EM in drug discovery[J]. Military Medical Research,2023,10(1).
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APA |
Zhu, Kong-Fu.,Yuan, Chuang.,Du, Yong-Ming.,Sun, Kai-Lei.,Zhang, Xiao-Kang.,...&Zhang, Hua-Wei.(2023).Applications and prospects of cryo-EM in drug discovery.Military Medical Research,10(1).
|
MLA |
Zhu, Kong-Fu,et al."Applications and prospects of cryo-EM in drug discovery".Military Medical Research 10.1(2023).
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