| Title | Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review |
| Author | |
| Corresponding Author | Chen, Lei |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 1022-1336
|
| EISSN | 1521-3927
|
| Abstract | The mineralization of type I collagen is a biological process occurring in vertebrates by which some hard tissues such as bone and dentin are constructed. Due to the extensive clinical needs for bone defect repair and remineralization of mineral-depleted dentin, biomimetic mineralization of collagen is attracting more and more interests. Synthetic analogs of noncollagenous proteins are necessary for directing the in vitro mineralization. In this paper, the function and mechanism of poly(acrylic acid) (PAA) in regulating the mineralization, especially intrafibrillar mineralization (IM) of collagen are reviewed. As two mineralization patterns (extrafibrillar and intrafibrillar) co-exist in natural hard tissues, differences between them in terms of microstructure, biodegradation, cytocompatibility, osteoinduction in vitro, and performance in vivo are systematically compared. Then the roles of PAA in biomimetic collagen IM within one-analog and two-analog systems are discussed, respectively. Moreover, mineralization of some self-mineralizable collagen matrices is described. Due to the interactions between collagen and PAA play a crucial role in the processes of collagen mineralization, some reference researches are also provided involving the collagen/PAA interactions in some other fields. Finally, this review is ended with an outlook for future potential improvements based on the collection of existing bottlenecks in this field. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Innovation/Entrepreneurship Program of Jiangsu Province[[2020] 30822]
; Science Foundation of National Key Laboratory of Science and Technology on Advanced Composites in Special Environments[JCKYS2021603C014]
|
| WOS Research Area | Polymer Science
|
| WOS Subject | Polymer Science
|
| WOS Accession No | WOS:000939445700001
|
| Publisher | |
| ESI Research Field | CHEMISTRY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/513446 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China 2.Jiangnan Univ, Coll Text Sci & Engn, Key Lab Ecotext, Minist Educ, Wuxi 214122, Peoples R China |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Chen, Lei,Zeng, Zhiyong,Li, Wenbing. Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2023.
|
| APA |
Chen, Lei,Zeng, Zhiyong,&Li, Wenbing.(2023).Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review.MACROMOLECULAR RAPID COMMUNICATIONS.
|
| MLA |
Chen, Lei,et al."Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review".MACROMOLECULAR RAPID COMMUNICATIONS (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
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