中文版 | English
Title

Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model

Author
Corresponding AuthorZhao,Feihu
Publication Years
2023-06-01
DOI
Source Title
EISSN
2590-0935
Volume18
Abstract
Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathology. In 3D cell culturing, porous scaffolds are used for housing the cells. It is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor (such as perfusion bioreactor). To calculate the WSS generated on cells within scaffolds, usually computational fluid dynamics (CFD) simulation is needed. However, the limitations of the computational method for WSS calculation are: (i) the high time cost of the CFD simulation (in particular for the highly irregular geometries); (ii) accessibility to the CFD model for some cell culturing experimentalists due to the knowledge gap. To address these limitations, this study aims to develop an empirical model for calculating the WSS based on scaffold permeability. This model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.
Keywords
URL[Source Record]
Language
English
SUSTech Authorship
Others
Scopus EID
2-s2.0-85150369848
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/515716
DepartmentSchool of System Design and Intelligent Manufacturing
Affiliation
1.Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering,Faculty of Science & Engineering,Swansea University,Swansea,SA1 8EN,United Kingdom
2.Welsh Centre for Printing and Coating,Faculty of Science and Engineering,Swansea University,Swansea,SA1 8EN,United Kingdom
3.Centre for Nanohealth,Swansea University Medical School and Faculty of Medicine,Health and Life Science,Swansea University,Swansea,SA3 5AU,United Kingdom
4.School of System Design and Intelligent Manufacturing,Southern University of Science and Technology,Shenzhen,518055,China
Recommended Citation
GB/T 7714
Ahmed,Husham,Bedding-Tyrrell,Matthew,Deganello,Davide,et al. Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model[J]. Medicine in Novel Technology and Devices,2023,18.
APA
Ahmed,Husham,Bedding-Tyrrell,Matthew,Deganello,Davide,Xia,Zhidao,Xiong,Yi,&Zhao,Feihu.(2023).Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model.Medicine in Novel Technology and Devices,18.
MLA
Ahmed,Husham,et al."Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model".Medicine in Novel Technology and Devices 18(2023).
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