中文版 | English
Title

CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma

Author
Corresponding AuthorChen,Guoan
Publication Years
2023-05-01
DOI
Source Title
ISSN
0024-3205
EISSN
1879-0631
Volume320
Abstract

Aims: Circular RNAs are widely expressed in various cancers and play important roles in tumorigenesis and tumor progression. The function and mechanism of circSMARCA5 in lung adenocarcinoma however remains unclear. Main methods: QRT-PCR analysis was applied for determining circSMARCA5 expression in lung adenocarcinoma patient tumor tissues and cells. Molecular biological assays were used for investigating the role of circSMARCA5 in lung adenocarcinoma progression. Luciferase reporter and bioinformatics assays were used for identifying the underlying mechanism. Key findings: In this study, we observed that circSMARCA5 expression was decreased in lung adenocarcinoma tissues but silencing of circSMARCA5 in lung adenocarcinoma cells inhibited cell proliferation, colony formation, migration and invasion. Mechanistically, we found EGFR, c-MYC and p21 were down-regulated upon circSMARCA5 knockdown. MiR-17-3p efficiently down- regulated EGFR expression via directly binding to EGFR mRNA. Significance: These studies suggest that circSMARCA5 functions as an oncogene via targeting miR-17-3p-EGFR axis and may represent a promising therapeutic target for lung adenocarcinoma.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China (NSFC)[
WOS Research Area
Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS Subject
Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS Accession No
WOS:000951537700001
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Scopus EID
2-s2.0-85149946975
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/515730
DepartmentSchool of Medicine
Affiliation
1.Department of Nuclear Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China
2.Department of Surgery,University of Michigan,Ann Arbor,United States
3.School of Medicine,Southern University of Science and Technology,Shenzhen,China
4.Department of Thoracic Surgery,Peking University People's Hospital,Beijing,China
5.Department of Thoracic Surgery,Tianjin Medical University,Tianjin,China
6.Department of Thoracic Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China
Corresponding Author AffilicationSchool of Medicine
Recommended Citation
GB/T 7714
Geng,Qianqian,Zhao,Huijie,Zhou,Zhiqing,et al. CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma[J]. LIFE SCIENCES,2023,320.
APA
Geng,Qianqian.,Zhao,Huijie.,Zhou,Zhiqing.,Chen,Xiuyuan.,Zhao,Honglin.,...&Chen,Guoan.(2023).CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma.LIFE SCIENCES,320.
MLA
Geng,Qianqian,et al."CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma".LIFE SCIENCES 320(2023).
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