中文版 | English
Title

Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice

Author
Corresponding AuthorCheng,Longzhen
Joint first authorHuo,Jiantao; Du,Feng; Duan,Kaifang; Yin,Guangjuan; Liu,Xi
Publication Years
2023-04-25
DOI
Source Title
ISSN
2211-1247
EISSN
2211-1247
Volume42Issue:4
Abstract

Mechanical allodynia (MA) represents one prevalent symptom of chronic pain. Previously we and others have identified spinal and brain circuits that transmit or modulate the initial establishment of MA. However, brain-derived descending pathways that control the laterality and duration of MA are still poorly understood. Here we report that the contralateral brain-to-spinal circuits, from Oprm1 neurons in the lateral parabrachial nucleus (lPBN), via Pdyn neurons in the dorsal medial regions of hypothalamus (dmH), to the spinal dorsal horn (SDH), act to prevent nerve injury from inducing contralateral MA and reduce the duration of bilateral MA induced by capsaicin. Ablating/silencing dmH-projecting lPBN neurons or SDH-projecting dmH neurons, deleting Dyn peptide from dmH, or blocking spinal κ-opioid receptors all led to long-lasting bilateral MA. Conversely, activation of dmH neurons or their axonal terminals in SDH can suppress sustained bilateral MA induced by lPBN lesion.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; 共同第一 ; Corresponding
Funding Project
Basic and Applied Basic Research Foundation of Guangdong Province[32025017] ; Health Commission of Guang-dong Province[32170996] ; Shenzhen Key Laboratory of Gene Regulationand Systems Biology[31571085] ; null[2021SHIBS0002] ; null[2019A1515010041] ; null[A2021319] ; null[ZDSYS20200811144002008]
WOS Research Area
Cell Biology
WOS Subject
Cell Biology
WOS Accession No
WOS:000962827000001
Publisher
Scopus EID
2-s2.0-85150430161
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/515735
DepartmentSchool of Life Sciences
生命科学学院_生物系
Affiliation
1.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Biology,Brain Research Center,Southern University of Science and Technology,Shenzhen,518055,China
3.Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,518055,China
4.Division of Life Sciences and Medicine,CAS Key Laboratory of Brain Function and Diseases,University of Science and Technology of China,Hefei,230027,China
First Author AffilicationSchool of Life Sciences
Corresponding Author AffilicationSchool of Life Sciences;  Department of Biology
First Author's First AffilicationSchool of Life Sciences
Recommended Citation
GB/T 7714
Huo,Jiantao,Du,Feng,Duan,Kaifang,et al. Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice[J]. Cell Reports,2023,42(4).
APA
Huo,Jiantao.,Du,Feng.,Duan,Kaifang.,Yin,Guangjuan.,Liu,Xi.,...&Cheng,Longzhen.(2023).Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice.Cell Reports,42(4).
MLA
Huo,Jiantao,et al."Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice".Cell Reports 42.4(2023).
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