Title | Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice |
Author | |
Corresponding Author | Cheng,Longzhen |
Joint first author | Huo,Jiantao; Du,Feng; Duan,Kaifang; Yin,Guangjuan; Liu,Xi |
Publication Years | 2023-04-25
|
DOI | |
Source Title | |
ISSN | 2211-1247
|
EISSN | 2211-1247
|
Volume | 42Issue:4 |
Abstract | Mechanical allodynia (MA) represents one prevalent symptom of chronic pain. Previously we and others have identified spinal and brain circuits that transmit or modulate the initial establishment of MA. However, brain-derived descending pathways that control the laterality and duration of MA are still poorly understood. Here we report that the contralateral brain-to-spinal circuits, from Oprm1 neurons in the lateral parabrachial nucleus (lPBN), via Pdyn neurons in the dorsal medial regions of hypothalamus (dmH), to the spinal dorsal horn (SDH), act to prevent nerve injury from inducing contralateral MA and reduce the duration of bilateral MA induced by capsaicin. Ablating/silencing dmH-projecting lPBN neurons or SDH-projecting dmH neurons, deleting Dyn peptide from dmH, or blocking spinal κ-opioid receptors all led to long-lasting bilateral MA. Conversely, activation of dmH neurons or their axonal terminals in SDH can suppress sustained bilateral MA induced by lPBN lesion. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | First
; 共同第一
; Corresponding
|
Funding Project | Basic and Applied Basic Research Foundation of Guangdong Province[32025017]
; Health Commission of Guang-dong Province[32170996]
; Shenzhen Key Laboratory of Gene Regulationand Systems Biology[31571085]
; null[2021SHIBS0002]
; null[2019A1515010041]
; null[A2021319]
; null[ZDSYS20200811144002008]
|
WOS Research Area | Cell Biology
|
WOS Subject | Cell Biology
|
WOS Accession No | WOS:000962827000001
|
Publisher | |
Scopus EID | 2-s2.0-85150430161
|
Data Source | Scopus
|
Citation statistics |
Cited Times [WOS]:0
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/515735 |
Department | School of Life Sciences 生命科学学院_生物系 |
Affiliation | 1.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China 2.Department of Biology,Brain Research Center,Southern University of Science and Technology,Shenzhen,518055,China 3.Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,518055,China 4.Division of Life Sciences and Medicine,CAS Key Laboratory of Brain Function and Diseases,University of Science and Technology of China,Hefei,230027,China |
First Author Affilication | School of Life Sciences |
Corresponding Author Affilication | School of Life Sciences; Department of Biology |
First Author's First Affilication | School of Life Sciences |
Recommended Citation GB/T 7714 |
Huo,Jiantao,Du,Feng,Duan,Kaifang,et al. Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice[J]. Cell Reports,2023,42(4).
|
APA |
Huo,Jiantao.,Du,Feng.,Duan,Kaifang.,Yin,Guangjuan.,Liu,Xi.,...&Cheng,Longzhen.(2023).Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice.Cell Reports,42(4).
|
MLA |
Huo,Jiantao,et al."Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice".Cell Reports 42.4(2023).
|
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