Title | Signaling Pathways That Are Influenced by SHANK3 Mutation and Related Treatment for Autism |
Author | |
Corresponding Author | Han, Yixiong |
DOI | |
Publication Years | 2022
|
Conference Name | 2022 International Conference on Biomedical and Intelligent Systems, IC-BIS 2022
|
ISSN | 0277-786X
|
EISSN | 1996-756X
|
ISBN | 9781510660212
|
Source Title | |
Volume | 12458
|
Conference Date | June 24, 2022 - June 26, 2022
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Conference Place | Chengdu, China
|
Author of Source | Academic Exchange Information Center (AEIC)
|
Publisher | |
Abstract | Autism (classical autism) is a neurodevelopmental disorder which is characterized by language delay, social impairment, repeated behaviors and hypophrenia in clinic. Recently, researches on autism have increased for the increasing prevalence of autism around the world. Genetic factors and environmental factors are considered as two main etiologies of autism. Hundreds of genes that are related to dendrite growth, synapse formation and neuronal function are identified as autism-associated genes. It is hard to totally understand the pathogenesis of autism due to the heterogeneous etiology of autism. Shank3 gene encodes an important scaffold protein which is involved in the formation of PSD. Mutations of Shank3 gene are strongly related to autism. Especially, the 22q13.3-deletion that results in the haploinsufficiency of SHANK3 leads to Phelan-McDermid syndrome. In order to find out how Shank3 mutations cause autism in molecular level, this review summarizes the relationship between SHANK3 and signaling pathways that are influenced by Shank3 mutations with current literature. In addition, possible intervening strategies towards SHANK3-related autism are collected for their potential in treating autism. © 2022 SPIE. All rights reserved. |
SUSTech Authorship | First
; Corresponding
|
Language | English
|
Indexed By | |
EI Accession Number | 20230113327417
|
EI Keywords | Diseases
; Photonics
; Scaffolds (biology)
; Signaling
|
ESI Classification Code | Biomedical Engineering:461.1
; Biological Materials and Tissue Engineering:461.2
; Light/Optics:741.1
; Optical Devices and Systems:741.3
|
Data Source | EV Compendex
|
Citation statistics |
Cited Times [WOS]:0
|
Document Type | Conference paper |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/519761 |
Affiliation | The Southern University of Science and Technology, Taoyuan Street, Shenzhen, China |
First Author Affilication | Southern University of Science and Technology |
Corresponding Author Affilication | Southern University of Science and Technology |
First Author's First Affilication | Southern University of Science and Technology |
Recommended Citation GB/T 7714 |
Han, Yixiong. Signaling Pathways That Are Influenced by SHANK3 Mutation and Related Treatment for Autism[C]//Academic Exchange Information Center (AEIC):SPIE,2022.
|
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