中文版 | English
Title

Signaling Pathways That Are Influenced by SHANK3 Mutation and Related Treatment for Autism

Author
Corresponding AuthorHan, Yixiong
DOI
Publication Years
2022
Conference Name
2022 International Conference on Biomedical and Intelligent Systems, IC-BIS 2022
ISSN
0277-786X
EISSN
1996-756X
ISBN
9781510660212
Source Title
Volume
12458
Conference Date
June 24, 2022 - June 26, 2022
Conference Place
Chengdu, China
Author of Source
Academic Exchange Information Center (AEIC)
Publisher
Abstract
Autism (classical autism) is a neurodevelopmental disorder which is characterized by language delay, social impairment, repeated behaviors and hypophrenia in clinic. Recently, researches on autism have increased for the increasing prevalence of autism around the world. Genetic factors and environmental factors are considered as two main etiologies of autism. Hundreds of genes that are related to dendrite growth, synapse formation and neuronal function are identified as autism-associated genes. It is hard to totally understand the pathogenesis of autism due to the heterogeneous etiology of autism. Shank3 gene encodes an important scaffold protein which is involved in the formation of PSD. Mutations of Shank3 gene are strongly related to autism. Especially, the 22q13.3-deletion that results in the haploinsufficiency of SHANK3 leads to Phelan-McDermid syndrome. In order to find out how Shank3 mutations cause autism in molecular level, this review summarizes the relationship between SHANK3 and signaling pathways that are influenced by Shank3 mutations with current literature. In addition, possible intervening strategies towards SHANK3-related autism are collected for their potential in treating autism.
© 2022 SPIE. All rights reserved.
SUSTech Authorship
First ; Corresponding
Language
English
Indexed By
EI Accession Number
20230113327417
EI Keywords
Diseases ; Photonics ; Scaffolds (biology) ; Signaling
ESI Classification Code
Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Light/Optics:741.1 ; Optical Devices and Systems:741.3
Data Source
EV Compendex
Citation statistics
Cited Times [WOS]:0
Document TypeConference paper
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/519761
DepartmentSouthern University of Science and Technology
Affiliation
The Southern University of Science and Technology, Taoyuan Street, Shenzhen, China
First Author AffilicationSouthern University of Science and Technology
Corresponding Author AffilicationSouthern University of Science and Technology
First Author's First AffilicationSouthern University of Science and Technology
Recommended Citation
GB/T 7714
Han, Yixiong. Signaling Pathways That Are Influenced by SHANK3 Mutation and Related Treatment for Autism[C]//Academic Exchange Information Center (AEIC):SPIE,2022.
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