中文版 | English
Title

Roles and therapeutic implications of m6A modification in cancer immunotherapy

Author
Corresponding AuthorZou, Chang
Publication Years
2023-03-07
DOI
Source Title
ISSN
1664-3224
Volume14
Abstract
Recent studies have demonstrated that N6-methyladenosine (m6A), the most abundant, dynamic, and reversible epigenetic RNA modification in eukaryotes, is regulated by a series of enzymes, including methyltransferases (writers), demethylases (erasers), and m6A recognition proteins (readers). Aberrant regulation of m6A modification is pivotal for tumorigenesis, progression, invasion, metastasis, and apoptosis of malignant tumors. Immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, as recognized by the 2018 Nobel Prize in Medicine and Physiology. However, not all cancer patients response to ICI therapy, which is thought to be the result of intricate immune escape mechanisms. Recently, numerous studies have suggested a novel role for m6A epigenetic modification in the regulation of tumor immune evasion. Herein, we review the relevant mechanisms of m6A regulators in regulating various key signaling pathways in cancer biology and how m6A epigenetic modifications regulate the expression of immune checkpoints, opening a new window to understand the roles and mechanisms of m6A epigenetic modifications in regulating tumor immune evasion. In addition, we highlight the prospects and development directions of future combined immunotherapy strategies based on m6A modification targeting, providing directions for promoting the treatment outcomes of immune checkpoint inhibitors.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:000950733500001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/523910
DepartmentShenzhen People's Hospital
Affiliation
1.Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, Guangxi Key Lab Biotargeting Theranost,Guangxi Tal, Nanning, Guangxi, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Dept Clin Med Res Ctr, Affiliated Hosp 1,Clin Med Coll 2,Shenzhen People, Shenzhen, Peoples R China
3.Shenzhen Univ, Int Canc Ctr, Dept Pharmacol, Guangdong Prov Key Lab Reg Immun & Dis,Hlth Sci Ct, Shenzhen, Peoples R China
4.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Dermatol, Shenzhen, Peoples R China
5.Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China
6.Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Publ Serv Platform Tumor Precis Med & Mol, Clin Med Coll 2, Shenzhen, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Pan, Juan,Huang, Tuxiong,Deng, Zhenjun,et al. Roles and therapeutic implications of m6A modification in cancer immunotherapy[J]. FRONTIERS IN IMMUNOLOGY,2023,14.
APA
Pan, Juan,Huang, Tuxiong,Deng, Zhenjun,&Zou, Chang.(2023).Roles and therapeutic implications of m6A modification in cancer immunotherapy.FRONTIERS IN IMMUNOLOGY,14.
MLA
Pan, Juan,et al."Roles and therapeutic implications of m6A modification in cancer immunotherapy".FRONTIERS IN IMMUNOLOGY 14(2023).
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