Hemoglobin level is negatively associated with sarcopenia and its components in Chinese aged 60 and above

Liu, Qiaoling1; You, Jiuhong2; Zhong, Min3; Wu, Zhigang4; Geng, Yunjie5; Huang, Cheng2,6

2023-03-13

10.3389/fpubh.2023.1081843

FRONTIERS IN PUBLIC HEALTH   Impact Factor & Quartile

2296-2565

IntroductionSarcopenia and low hemoglobin level are common in older adults. Few studies have evaluated the association between hemoglobin level and sarcopenia and with inconsistent findings. The multifaceted effects of sarcopenia on the human body and the high prevalence of anemia in the Chinese population make it necessary to explore the association between the two. MethodsUsing the China Health and Retirement Longitudinal Study (CHARLS), we explored the association between hemoglobin with sarcopenia and its components in the Chinese population aged 60 and above. Multivariate logistic and Cox proportional hazards models were constructed to examine the association of hemoglobin level with sarcopenia and sarcopenia components in individuals aged 60 years or above. The subgroup analysis covered residence, body mass index level, drinking status, and smoking status were conducted. The possible difference of associations between sexes was also explored. ResultsWith a total of 3,055 people, the hemoglobin concentration in people without sarcopenia, possible sarcopenia, and sarcopenia are 14.34 +/- 2.22, 14.64 +/- 2.27, and 13.58 +/- 2.02 g/dl, respectively. Cross-sectional analysis showed strong evidence that hemoglobin was negatively associated with sarcopenia [Odds Ratio (OR) = 0.95, 95% Confidence Interval (CI): 0.90-0.99] and low height-adjusted appendicular skeletal muscle mass (OR = 0.91, 95% CI: 0.86-0.97). On average, a per 1 g/dl higher hemoglobin level was associated with 5% lower odds of sarcopenia (OR = 0.95, 95% CI: 0.90-0.98). The cohort study of 1,022 people demonstrated a statistically significant negative association of hemoglobin level with low physical performance [Hazard Ratio (HR) = 0.92, 95% CI: 0.85-0.99], merely with sarcopenia (HR = 0.92, 95% CI: 0.84-1.00) and skeletal muscle mass (HR = 0.95, 95% CI: 0.80-1.00). Sex-specific analysis suggested hemoglobin's association with sarcopenia, muscle mass, and physical performance in all sexes, with weaker magnitudes in females. Hemoglobin in urban residents and people with high body mass index (BMI) has a larger magnitude of the negative association with sarcopenia. DiscussionHemoglobin level associates with sarcopenia, muscle mass, and physical performance in the Chinese population aged 60 and above, with sex-specific, residence-specific, and BMI-specific effects.

China adult aging hemoglobin sarcopenia epidemiology

SCI ; SSCI

English

Others

1.3.5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University[2021HXFH063]

Public, Environmental & Occupational Health

Public, Environmental & Occupational Health

WOS:000956802200001

FRONTIERS MEDIA SA

Web of Science

1.Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland
2.Sichuan Univ, West China Hosp, Dept Rehabil Med, Chengdu, Sichuan, Peoples R China
3.Nanjing Med Univ, Affiliated Brain Hosp, Dept Geriatr Neurol, Nanjing, Jiangsu, Peoples R China
4.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Guangdong, Peoples R China
5.Natl Bur Stat, Res Inst Stat Sci, Beijing, Peoples R China
6.Sichuan Univ, West China Hosp, Key Lab Rehabil Med Sichuan Prov, Chengdu, Sichuan, Peoples R China

Liu, Qiaoling,You, Jiuhong,Zhong, Min,et al. Hemoglobin level is negatively associated with sarcopenia and its components in Chinese aged 60 and above[J]. FRONTIERS IN PUBLIC HEALTH,2023,11.

Liu, Qiaoling,You, Jiuhong,Zhong, Min,Wu, Zhigang,Geng, Yunjie,&Huang, Cheng.(2023).Hemoglobin level is negatively associated with sarcopenia and its components in Chinese aged 60 and above.FRONTIERS IN PUBLIC HEALTH,11.

Liu, Qiaoling,et al."Hemoglobin level is negatively associated with sarcopenia and its components in Chinese aged 60 and above".FRONTIERS IN PUBLIC HEALTH 11(2023).