Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis

Liang, Zhilin1; Liao, Weiming2; Chen, Qifu3; Li, Hui1; Ye, Meiling1; Zou, Jin4; Deng, Guofang1; Zhang, Peize1

2023

10.2147/IDR.S401281

INFECTION AND DRUG RESISTANCE   Impact Factor & Quartile

1178-6973

Drug-resistant tuberculous meningitis (TBM) is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long-tunneled external ventricular drainage (LTEVD). Molecular test and phenotypic drug sensitivity test (DST) of Mycobacterium tuberculosis in cerebrospinal fluid (CSF) showed that the isolate was resistant to both rifampin and fluoroquinolones. An anti-tuberculous regimen of isoniazid, pyrazinamide, cycloserine, moxifloxacin, clofazimine, and linezolid was tailored accordingly. We monitored the drug concentration in his plasma and CSF before (at 0-hour) and after anti-TB drugs administration (at 1-hour, 2-hour, 6-hour, and 12-hour) on 10th day after treatment initiation. We hope to provide reference values of drug exposures in plasma and CSF for patients with pre-XDR-TBM.

pre-extensive drug resistant TB tuberculous meningitis pharmacokinetics long-tunneled external ventricular drain drug concentration

SCI

English

First ; Corresponding

Summit Plan for Foshan High level Hospital Construction[FSSYKF-2020001] ; Guangdong Provincial Clinical Research Center for Tuberculosis Project[2020B1111170014] ; Project of Shenzhen Third People's Hospital["G2021023","G2021022"]

Infectious Diseases ; Pharmacology & Pharmacy

Infectious Diseases ; Pharmacology & Pharmacy

WOS:000957950700001

DOVE MEDICAL PRESS LTD

Web of Science

1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Pulm Med & TB, Shenzhen, Peoples R China
2.Jiangxi Prov Canc Hosp, Dept Thorac Oncol, Nanchang, Peoples R China
3.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Neurosurg, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Clin Lab, Shenzhen, Peoples R China

Liang, Zhilin,Liao, Weiming,Chen, Qifu,et al. Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis[J]. INFECTION AND DRUG RESISTANCE,2023,16.

Liang, Zhilin.,Liao, Weiming.,Chen, Qifu.,Li, Hui.,Ye, Meiling.,...&Zhang, Peize.(2023).Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis.INFECTION AND DRUG RESISTANCE,16.

Liang, Zhilin,et al."Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis".INFECTION AND DRUG RESISTANCE 16(2023).