The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy

Sun, Liping1,2; Zi, Xinyi1; Wang, Zhen1; Zhang, Xinzhou1

2023-03-22

10.1186/s12882-023-03106-4

BMC NEPHROLOGY   Impact Factor & Quartile

1471-2369

BackgroundImmunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy worldwide, and lacks the effective treatment. The study was aimed to investigate the clinical efficacy of fluticasone propionate aerosol combined with angiotensin converting enzyme inhibitor / angiotensin receptor blocker (ACEI/ARB) in the treatment of IgAN.Methods142 patients with biopsy-proven IgAN at Shenzhen People?s hospital from June 2018 to June 2020 were enrolled. The patients were randomly divided into the supportive care plus fluticasone group and the supportive care group. The patients of the supportive care plus fluticasone group were treated with fluticasone propionate aerosol (250 ?g Bid) combined with ACEI/ARB, while the supportive care group was merely treated with ACEI/ARB. The patients were followed up at 3, 6 and 9 months after enrollment. Primary outcomes include changes in proteinuria and estimated glomerular filtration rate (eGFR).ResultsThe level of proteinuria in the supportive care plus fluticasone group was significantly lower compared with the supportive care group at 0, 3, 6 and 9 months. Meanwhile, during the follow-up period, no serious adverse events were recorded during the study in either group. However, fluticasone treatment did not alleviate the decline in eGFR.ConclusionFluticasone propionate aerosol combined with ACEI/ARB can reduce the level of proteinuria in thetreatment of IgAN, and has no significant effects on renal function.

IgA nephropathy Fluticasone propionate aerosol Proteinuria Clinical efficacy

SCI

English

Corresponding

Urology & Nephrology

Urology & Nephrology

WOS:000951332700005

BMC

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Nephrol,Shenzhen Key Lab Renal, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China

Sun, Liping,Zi, Xinyi,Wang, Zhen,et al. The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy[J]. BMC NEPHROLOGY,2023,24(1).

Sun, Liping,Zi, Xinyi,Wang, Zhen,&Zhang, Xinzhou.(2023).The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy.BMC NEPHROLOGY,24(1).

Sun, Liping,et al."The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy".BMC NEPHROLOGY 24.1(2023).