中文版 | English
Title

The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy

Author
Corresponding AuthorSun, Liping
Publication Years
2023-03-22
DOI
Source Title
EISSN
1471-2369
Volume24Issue:1
Abstract
BackgroundImmunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy worldwide, and lacks the effective treatment. The study was aimed to investigate the clinical efficacy of fluticasone propionate aerosol combined with angiotensin converting enzyme inhibitor / angiotensin receptor blocker (ACEI/ARB) in the treatment of IgAN.Methods142 patients with biopsy-proven IgAN at Shenzhen People?s hospital from June 2018 to June 2020 were enrolled. The patients were randomly divided into the supportive care plus fluticasone group and the supportive care group. The patients of the supportive care plus fluticasone group were treated with fluticasone propionate aerosol (250 ?g Bid) combined with ACEI/ARB, while the supportive care group was merely treated with ACEI/ARB. The patients were followed up at 3, 6 and 9 months after enrollment. Primary outcomes include changes in proteinuria and estimated glomerular filtration rate (eGFR).ResultsThe level of proteinuria in the supportive care plus fluticasone group was significantly lower compared with the supportive care group at 0, 3, 6 and 9 months. Meanwhile, during the follow-up period, no serious adverse events were recorded during the study in either group. However, fluticasone treatment did not alleviate the decline in eGFR.ConclusionFluticasone propionate aerosol combined with ACEI/ARB can reduce the level of proteinuria in thetreatment of IgAN, and has no significant effects on renal function.
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URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
WOS Research Area
Urology & Nephrology
WOS Subject
Urology & Nephrology
WOS Accession No
WOS:000951332700005
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/523993
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Nephrol,Shenzhen Key Lab Renal, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Sun, Liping,Zi, Xinyi,Wang, Zhen,et al. The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy[J]. BMC NEPHROLOGY,2023,24(1).
APA
Sun, Liping,Zi, Xinyi,Wang, Zhen,&Zhang, Xinzhou.(2023).The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy.BMC NEPHROLOGY,24(1).
MLA
Sun, Liping,et al."The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy".BMC NEPHROLOGY 24.1(2023).
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