中文版 | English
Title

Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles

Author
Corresponding AuthorXu, Ming-Hua
Publication Years
2023-02-01
DOI
Source Title
ISSN
0022-3263
EISSN
1520-6904
Abstract
A highly regiospecific vinylogous carbene insertion protocol for direct asymmetric C-H functionalization of indoles with arylvinyldiazoacetates has been developed. Under the catalysis of simple Rh(I)/chiral diene complexes, the reaction occurs solely at the vinylogous position of the vinylcarbenoid with exceptional E selectivity and enantiocontrol. It provides an efficient way to obtain an interesting class of chiral indole scaffolds bearing an alpha,beta-unsaturated ester unit and a gem-diaryl carbon stereocenter in good yields (<99%) with excellent enantioselectivities (<96%) at room temperature.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China["21971103","21672229"] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Shenzhen Science and Technology Innovation Commission[JCYJ20200109141408054]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Organic
WOS Accession No
WOS:000960615000001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/524005
DepartmentShenzhen Grubbs Institute
理学院_化学系
Affiliation
1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China
4.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
Corresponding Author AffilicationShenzhen Grubbs Institute;  Department of Chemistry
Recommended Citation
GB/T 7714
Zhu, Dong-Xing,Xu, Ming-Hua. Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles[J]. JOURNAL OF ORGANIC CHEMISTRY,2023.
APA
Zhu, Dong-Xing,&Xu, Ming-Hua.(2023).Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles.JOURNAL OF ORGANIC CHEMISTRY.
MLA
Zhu, Dong-Xing,et al."Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles".JOURNAL OF ORGANIC CHEMISTRY (2023).
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