| Title | Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles |
| Author | |
| Corresponding Author | Xu, Ming-Hua |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 0022-3263
|
| EISSN | 1520-6904
|
| Abstract | A highly regiospecific vinylogous carbene insertion protocol for direct asymmetric C-H functionalization of indoles with arylvinyldiazoacetates has been developed. Under the catalysis of simple Rh(I)/chiral diene complexes, the reaction occurs solely at the vinylogous position of the vinylcarbenoid with exceptional E selectivity and enantiocontrol. It provides an efficient way to obtain an interesting class of chiral indole scaffolds bearing an alpha,beta-unsaturated ester unit and a gem-diaryl carbon stereocenter in good yields (<99%) with excellent enantioselectivities (<96%) at room temperature. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China["21971103","21672229"]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
; Shenzhen Science and Technology Innovation Commission[JCYJ20200109141408054]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:000960615000001
|
| Publisher | |
| ESI Research Field | CHEMISTRY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/524005 |
| Department | Shenzhen Grubbs Institute 理学院_化学系 |
| Affiliation | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China 4.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China |
| Corresponding Author Affilication | Shenzhen Grubbs Institute; Department of Chemistry |
| Recommended Citation GB/T 7714 |
Zhu, Dong-Xing,Xu, Ming-Hua. Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles[J]. JOURNAL OF ORGANIC CHEMISTRY,2023.
|
| APA |
Zhu, Dong-Xing,&Xu, Ming-Hua.(2023).Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles.JOURNAL OF ORGANIC CHEMISTRY.
|
| MLA |
Zhu, Dong-Xing,et al."Rhodium(I)-Catalyzed Direct Enantioselective C-H Functionalization of Indoles".JOURNAL OF ORGANIC CHEMISTRY (2023).
|
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