Title | Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr |
Author | |
Corresponding Author | Luo, Dahai; Yang, Liang |
Publication Years | 2023
|
DOI | |
Source Title | |
ISSN | 2001-0370
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Volume | 21 |
Abstract | Pseudomonas aeruginosa is a leading cause of hospital-acquired infections. Treatment of P. aeruginosa in-fections is difficult given its multiple virulence mechanisms, intrinsic antibiotic resistance mechanisms, and biofilm-forming ability. Auranofin, an approved oral gold compound for rheumatoid arthritis treatment, was recently reported to inhibit the growth of multiple bacterial species. Here, we identify P. aeruginosa's global virulence factor regulator Vfr as one target of auranofin. We report the mechanistic insights into the in-hibitory mechanism of auranofin and gold(I) analogues to Vfr through structural, biophysical, and pheno-typic inhibition studies. This work suggests that auranofin and gold(I) analogues have potential to be developed as anti-virulence drugs against P. aeruginosa.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creative-commons.org/licenses/by/4.0/). |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | First
; Corresponding
|
Funding Project | Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 1 and Tier 2["2018-T1-002-010","2016-T2-2-097"]
; Guangdong Natural Science Foundation for Distinguished Young Scholar[2020B1515020003]
; National Key Research and Development Program of China[2022YFC2304700]
; National Natural Science Foundation of China["32270196","32200155"]
; Guangdong Basic and Applied Basic Research Foundation[2019A1515110640]
; Shenzhen Overseas High-level Talent Team[KQTD20200909113758004]
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WOS Research Area | Biochemistry & Molecular Biology
; Biotechnology & Applied Microbiology
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WOS Subject | Biochemistry & Molecular Biology
; Biotechnology & Applied Microbiology
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WOS Accession No | WOS:000959891400001
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Publisher | |
Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:1
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/524019 |
Department | The Third People's Hospital of Shenzhen 南方科技大学医学院 南方科技大学第一附属医院 |
Affiliation | 1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis, Shenzhen 518112, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Guangdong, Peoples R China 3.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore 4.Nanyang Technol Univ, NTU Inst Struct Biol, EMB 06-01,59 Nanyang Dr, Singapore 636921, Singapore 5.Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn SCELSE, Singapore, Singapore 6.Guanghua Sci & Technol Res Inst Guangdong Co Ltd, Guangzhou, Peoples R China |
First Author Affilication | The Third People's Hospital of Shenzhen; Shenzhen People's Hospital; School of Medicine |
Corresponding Author Affilication | The Third People's Hospital of Shenzhen; Shenzhen People's Hospital; School of Medicine |
First Author's First Affilication | The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Zhang, Yingdan,Chew, Bing Liang Alvin,Wang, Jing,et al. Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2023,21.
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APA |
Zhang, Yingdan.,Chew, Bing Liang Alvin.,Wang, Jing.,Yuan, Mingjun.,Yam, Joey Kuok Hoong.,...&Yang, Liang.(2023).Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,21.
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MLA |
Zhang, Yingdan,et al."Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 21(2023).
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