中文版 | English
Title

Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr

Author
Corresponding AuthorLuo, Dahai; Yang, Liang
Publication Years
2023
DOI
Source Title
ISSN
2001-0370
Volume21
Abstract
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections. Treatment of P. aeruginosa in-fections is difficult given its multiple virulence mechanisms, intrinsic antibiotic resistance mechanisms, and biofilm-forming ability. Auranofin, an approved oral gold compound for rheumatoid arthritis treatment, was recently reported to inhibit the growth of multiple bacterial species. Here, we identify P. aeruginosa's global virulence factor regulator Vfr as one target of auranofin. We report the mechanistic insights into the in-hibitory mechanism of auranofin and gold(I) analogues to Vfr through structural, biophysical, and pheno-typic inhibition studies. This work suggests that auranofin and gold(I) analogues have potential to be developed as anti-virulence drugs against P. aeruginosa.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creative-commons.org/licenses/by/4.0/).
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 1 and Tier 2["2018-T1-002-010","2016-T2-2-097"] ; Guangdong Natural Science Foundation for Distinguished Young Scholar[2020B1515020003] ; National Key Research and Development Program of China[2022YFC2304700] ; National Natural Science Foundation of China["32270196","32200155"] ; Guangdong Basic and Applied Basic Research Foundation[2019A1515110640] ; Shenzhen Overseas High-level Talent Team[KQTD20200909113758004]
WOS Research Area
Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS Subject
Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS Accession No
WOS:000959891400001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/524019
DepartmentThe Third People's Hospital of Shenzhen
南方科技大学医学院
南方科技大学第一附属医院
Affiliation
1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis, Shenzhen 518112, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Guangdong, Peoples R China
3.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore
4.Nanyang Technol Univ, NTU Inst Struct Biol, EMB 06-01,59 Nanyang Dr, Singapore 636921, Singapore
5.Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn SCELSE, Singapore, Singapore
6.Guanghua Sci & Technol Res Inst Guangdong Co Ltd, Guangzhou, Peoples R China
First Author AffilicationThe Third People's Hospital of Shenzhen;  Shenzhen People's Hospital;  School of Medicine
Corresponding Author AffilicationThe Third People's Hospital of Shenzhen;  Shenzhen People's Hospital;  School of Medicine
First Author's First AffilicationThe Third People's Hospital of Shenzhen;  Shenzhen People's Hospital
Recommended Citation
GB/T 7714
Zhang, Yingdan,Chew, Bing Liang Alvin,Wang, Jing,et al. Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2023,21.
APA
Zhang, Yingdan.,Chew, Bing Liang Alvin.,Wang, Jing.,Yuan, Mingjun.,Yam, Joey Kuok Hoong.,...&Yang, Liang.(2023).Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,21.
MLA
Zhang, Yingdan,et al."Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 21(2023).
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