中文版 | English
Title

The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy

Author
Publication Years
2023-07-01
DOI
Source Title
ISSN
1878-5352
Volume16Issue:7
Abstract
Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT.
Keywords
URL[Source Record]
Language
English
SUSTech Authorship
Others
Scopus EID
2-s2.0-85151535025
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/524099
DepartmentSouthern University of Science and Technology Hospital
Affiliation
1.Departement of General Surgery,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,121000,China
2.Discipline Construction Office,Southern University of Science and Technology Hospital,Shenzhen,518071,China
3.Information Resource Center,Institute of Scientific and Technical Information of China,Beijing,100105,China
4.Department of Gastroenterology,South China Hospital,Medical School,Shenzhen University,Shenzhen,518116,China
5.Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming,650500,China
6.Medical School,Kunming University of Science and Technology,Kunming,650500,China
7.Department of Oncology,Qingdao Municipal Hospital,Qingdao,266000,China
Recommended Citation
GB/T 7714
Li,Dongsheng,Fan,Yue,Liu,Miaomiao,et al. The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy[J]. Arabian Journal of Chemistry,2023,16(7).
APA
Li,Dongsheng,Fan,Yue,Liu,Miaomiao,Huang,Si Lin,&Wang,Shasha.(2023).The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy.Arabian Journal of Chemistry,16(7).
MLA
Li,Dongsheng,et al."The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy".Arabian Journal of Chemistry 16.7(2023).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Li,Dongsheng]'s Articles
[Fan,Yue]'s Articles
[Liu,Miaomiao]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Li,Dongsheng]'s Articles
[Fan,Yue]'s Articles
[Liu,Miaomiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li,Dongsheng]'s Articles
[Fan,Yue]'s Articles
[Liu,Miaomiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.