中文版 | English
Title

Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study

Author
Corresponding AuthorBai,Yana
Publication Years
2023-06-01
DOI
Source Title
ISSN
1877-7821
EISSN
1877-783X
Volume84
Abstract
Background: The risk of hepatocellular carcinoma (HCC) is associated with a variety of factors. However, the possible association between the abnormal metabolism of fasting plasma glucose (FPG) and alanine aminotransferase (ALT) and the risk of HCC has not been widely studied. We examined this relationship based on a prospective cohort study. Methods: 162 first-attack HCC cases during three follow-up periods (2014–2020) were selected as the case group. A control group of 648 participants was obtained by 1:4 matching of age (± 2 years) and sex with noncancer participants in the same period. Conditional logistic regression models, restricted cubic spline models, additive interaction models, and generalized additive models were used to explore the effects of FPG and ALT on the risk of HCC. Results: After correction for confounding factors, we found that abnormal FPG and elevated ALT increased the risk of HCC, respectively. Compared with the normal FPG group, the risk of HCC was significantly increased in the impaired fasting glucose (IFG) (OR = 1.91, 95 %CI: 1.04, 3.50) and diabetes groups (OR = 2.12, 95 %CI: 1.24, 3.63). Compared with the lowest quartile of ALT, subjects in the fourth quartile had an 84 % increased risk of HCC (OR = 1.84, 95 %CI: 1.05–3.21). Moreover, there was an interaction between FPG and ALT on the risk of HCC, and 74 % of the HCC risk could be attributed to their synergistic effect (AP = 0.74, 95 %CI: 0.56–0.92). Conclusion: Abnormal FPG and elevated ALT are independent risk factors for HCC, and they have a synergistic effect on the risk of HCC. Therefore, serum FPG and ALT levels should be monitored to prevent the development of HCC.
Keywords
URL[Source Record]
Language
English
SUSTech Authorship
Others
Funding Project
National Natural Science Foundation of China[81673248];
Scopus EID
2-s2.0-85151497245
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/524116
DepartmentSchool of Public Health and Emergency Management
Affiliation
1.Department of Epidemiology and Health Statistics,School of Public Health,Lanzhou University,Lanzhou,730000,China
2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Street,518055,China
Recommended Citation
GB/T 7714
Zhang,Lizhen,Wang,Zhongge,Chen,Ruirui,et al. Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study[J]. Cancer Epidemiology,2023,84.
APA
Zhang,Lizhen.,Wang,Zhongge.,Chen,Ruirui.,Cheng,Zhiyuan.,Yang,Jingli.,...&Bai,Yana.(2023).Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study.Cancer Epidemiology,84.
MLA
Zhang,Lizhen,et al."Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study".Cancer Epidemiology 84(2023).
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