Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial

Guan，Qing1,2; Guo，Ze hong1; Dai，Da mao3; Fan，Zhe xiang1; Chen，Jian1; Wu，Shu lin1; Liu，Xiao min4; Miao，Yong1; Hu，Zhi qi1; Qu，Qian1

2023-05-01

10.1016/j.biopha.2023.114517

Biomedicine and Pharmacotherapy   Impact Factor & Quartile

0753-3322

1950-6007

Background: Platelet lysate (PL), a novel platelet derivative, has been widely used in regenerative medicine and is a potential therapy for improving hair growth. It is necessary to fully clarify the potential mechanism and evaluate preliminary clinical effect of PL on hair growth. Methods: We used the C57BL/6 model, organ-cultured hair follicles, and RNA-seq analysis to explore the mechanisms of PL regulating hair growth. Then, we performed a randomized, controlled, double-blind study of 107 AGA patients to verify the therapeutic efficacy of PL. Results: The results confirmed that PL improved hair growth and accelerated hair cycling in mice. Organ-cultured hair follicle evaluation confirmed that PL prolonged anagen remarkably and down-regulated IL-6, C-FOS, and p-STAT5a. Clinically, diameter, hair counts, absolute anagen counts and changes from baseline in the PL group showed a significant improvement at 6 months. Conclusions: We elucidated the specific molecular mechanism of PL action on hair growth and proved equal changes in hair follicle performance after PL vs PRP in AGA patients. This study provided novel knowledge of PL, making it ideal for AGA.

Androgenic alopecia Hair follicle Hair growth Platelet lysate Platelet-rich plasma

SCI

English

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Natural Science Foundation of Guangdong Province[2019A1515012170];Natural Science Foundation of Guangdong Province[2020A1515110700];National Natural Science Foundation of China[81701929];National Natural Science Foundation of China[81902013];National Natural Science Foundation of China[81971889];National Natural Science Foundation of China[82103763];

WOS:000962504900001

2-s2.0-85150804284

Scopus

1.Department of Plastic and Aesthetic Surgery,Nan Fang Hospital,Southern Medical University,Guangzhou,China
2.Department of Plastic and Aesthetic Surgery,Guiyang First People's Hospital,Guiyang,China
3.Department of Plastic and Cosmetic Surgery,Shenzhen People's Hospital,Second Clinical Medical College of Jinan University Medical College,1st Affiliated Hospital of Southern University of Science and Technology,China
4.Department of Plastic and Aesthetic Surgery,clifford-hospital,Guangzhou,China

Guan，Qing,Guo，Ze hong,Dai，Da mao,et al. Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial[J]. Biomedicine and Pharmacotherapy,2023,161.

Guan，Qing.,Guo，Ze hong.,Dai，Da mao.,Fan，Zhe xiang.,Chen，Jian.,...&Qu，Qian.(2023).Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial.Biomedicine and Pharmacotherapy,161.

Guan，Qing,et al."Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial".Biomedicine and Pharmacotherapy 161(2023).