中文版 | English
Title

Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty

Author
Publication Years
2023-04-05
DOI
Source Title
EISSN
2045-2322
Volume13Issue:1
Abstract
Phthalate esters (PAEs) may act as estrogen receptor agonists, and their relationship with precocious puberty is a global health concern. However, their role in isolated premature thelarche (IPT) progression remains unclear. We conducted a cohort study investigating the relationship between IPT progression and urinary PAE metabolites. Girls with IPT aged 6-8 years were regularly followed up every three months for one year. Clinical data and urine PAE metabolite levels were collected. Participants who progressed to central precocious puberty (CPP) or early puberty (EP) had significantly higher ovarian volume, breast Tanner stage, and levels of the creatinine-adjusted urinary secondary oxidized di-2-ethylhexyl phthalate (DEHP) metabolites (Σ4DEHP). Breast Tanner stage (odds ratio [OR] = 7.041, p = 0.010), ovarian volume (OR = 3.603, p = 0.019), and Σ4DEHP (OR = 1.020, p = 0.005) were independent risk factors for IPT progression. For each 10 µg/g/Cr increase in the urine level of Σ4DEHP, the risk of progression from IPT to CPP/EP within one year increased by 20%. This study demonstrated that the breast Tanner stage, ovarian volume, and Σ4DEHP in urine were independent risk factors for IPT progression, and Σ4DEHP may be associated with the progression of IPT to CPP or EP.
URL[Source Record]
Language
English
SUSTech Authorship
Others
Scopus EID
2-s2.0-85151780468
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/524173
DepartmentSchool of Medicine
Affiliation
1.Department of Endocrinology,Shenzhen Children's Hospital,Shenzhen,China
2.Department of Endocrinology,Fujian Children's Hospital,Fuzhou,China
3.School of Medicine,Southern University of Science and Technology,Shenzhen,China
4.Department of Clinical Research,Shenzhen Children's Hospital,Shenzhen,China
5.Shenzhen Center for Disease Control and Prevention,Shenzhen,China
6.Central Laboratory,Longgang District Maternal and Child Healthcare Hospital,Shenzhen,China
Recommended Citation
GB/T 7714
Zheng,Xiuxin,Su,Huiping,Huang,Shurong,et al. Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty[J]. Scientific reports,2023,13(1).
APA
Zheng,Xiuxin.,Su,Huiping.,Huang,Shurong.,Su,Wei.,Zheng,Rongfei.,...&Su,Zhe.(2023).Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty.Scientific reports,13(1).
MLA
Zheng,Xiuxin,et al."Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty".Scientific reports 13.1(2023).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Zheng,Xiuxin]'s Articles
[Su,Huiping]'s Articles
[Huang,Shurong]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Zheng,Xiuxin]'s Articles
[Su,Huiping]'s Articles
[Huang,Shurong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng,Xiuxin]'s Articles
[Su,Huiping]'s Articles
[Huang,Shurong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.