Title | Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty |
Author | |
Publication Years | 2023-04-05
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DOI | |
Source Title | |
EISSN | 2045-2322
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Volume | 13Issue:1 |
Abstract | Phthalate esters (PAEs) may act as estrogen receptor agonists, and their relationship with precocious puberty is a global health concern. However, their role in isolated premature thelarche (IPT) progression remains unclear. We conducted a cohort study investigating the relationship between IPT progression and urinary PAE metabolites. Girls with IPT aged 6-8 years were regularly followed up every three months for one year. Clinical data and urine PAE metabolite levels were collected. Participants who progressed to central precocious puberty (CPP) or early puberty (EP) had significantly higher ovarian volume, breast Tanner stage, and levels of the creatinine-adjusted urinary secondary oxidized di-2-ethylhexyl phthalate (DEHP) metabolites (Σ4DEHP). Breast Tanner stage (odds ratio [OR] = 7.041, p = 0.010), ovarian volume (OR = 3.603, p = 0.019), and Σ4DEHP (OR = 1.020, p = 0.005) were independent risk factors for IPT progression. For each 10 µg/g/Cr increase in the urine level of Σ4DEHP, the risk of progression from IPT to CPP/EP within one year increased by 20%. This study demonstrated that the breast Tanner stage, ovarian volume, and Σ4DEHP in urine were independent risk factors for IPT progression, and Σ4DEHP may be associated with the progression of IPT to CPP or EP. |
URL | [Source Record] |
Language | English
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SUSTech Authorship | Others
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Scopus EID | 2-s2.0-85151780468
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Data Source | Scopus
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/524173 |
Department | School of Medicine |
Affiliation | 1.Department of Endocrinology,Shenzhen Children's Hospital,Shenzhen,China 2.Department of Endocrinology,Fujian Children's Hospital,Fuzhou,China 3.School of Medicine,Southern University of Science and Technology,Shenzhen,China 4.Department of Clinical Research,Shenzhen Children's Hospital,Shenzhen,China 5.Shenzhen Center for Disease Control and Prevention,Shenzhen,China 6.Central Laboratory,Longgang District Maternal and Child Healthcare Hospital,Shenzhen,China |
Recommended Citation GB/T 7714 |
Zheng,Xiuxin,Su,Huiping,Huang,Shurong,et al. Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty[J]. Scientific reports,2023,13(1).
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APA |
Zheng,Xiuxin.,Su,Huiping.,Huang,Shurong.,Su,Wei.,Zheng,Rongfei.,...&Su,Zhe.(2023).Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty.Scientific reports,13(1).
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MLA |
Zheng,Xiuxin,et al."Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty".Scientific reports 13.1(2023).
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