| Title | Auranofin inhibits virulence pathways in Pseudomonas aeruginosa |
| Author | |
| Corresponding Author | Givskov，Michael |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 0968-0896
|
| EISSN | 1464-3391
|
| Volume | 79 |
| Abstract | Pseudomonas aeruginosa is widely attributed as the leading cause of hospital-acquired infections. Due to intrinsic antibiotic resistance mechanisms and the ability to form biofilms, P. aeruginosa infections are challenging to treat. P. aeruginosa employs multiple virulence mechanisms to establish infections, many of which are controlled by the global virulence regulator Vfr. An attractive strategy to combat P. aeruginosa infections is thus the use of anti-virulence compounds. Here, we report the discovery that FDA-approved drug auranofin attenuates virulence pathways in P. aeruginosa, including quorum sensing (QS) and Type IV pili (TFP). We show that auranofin acts via multiple targets, one of which being Vfr. Consistent with inhibition of QS and TFP expression, we show that auranofin attenuates biofilm maturation, and when used in combination with colistin, displays strong synergy in eradicating P. aeruginosa biofilms. Auranofin may have immediate applications as an anti-virulence drug against P. aeruginosa infections. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | Ministry of Education Academic Research Fund Tier 2 grant[MOE2016-T2-1-104]
|
| WOS Research Area | Biochemistry & Molecular Biology
; Pharmacology & Pharmacy
; Chemistry
|
| WOS Subject | Biochemistry & Molecular Biology
; Chemistry, Medicinal
; Chemistry, Organic
|
| WOS Accession No | WOS:000963176000001
|
| Publisher | |
| ESI Research Field | CHEMISTRY
|
| Scopus EID | 2-s2.0-85146648255
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/524217 |
| Department | School of Medicine |
| Affiliation | 1.Singapore Center for Environmental Life Sciences Engineering (SCELSE),Nanyang Technological University,Singapore,637551,Singapore 2.Department of Chemistry,National University of Singapore,Singapore,117543,Singapore 3.School of Biological Sciences,Nanyang Technological University,Singapore,639798,Singapore 4.Costerton Biofilm Center,Department of Immunology and Microbiology,University of Copenhagen,DK- 2200,Denmark 5.School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,518055,China |
| Recommended Citation GB/T 7714 |
Yam，Joey Kuok Hoong,Tan，Leon Zhen Wei,Hong，Ziyan,et al. Auranofin inhibits virulence pathways in Pseudomonas aeruginosa[J]. Bioorganic and Medicinal Chemistry,2023,79.
|
| APA |
Yam，Joey Kuok Hoong.,Tan，Leon Zhen Wei.,Hong，Ziyan.,Salido，May Margarette Santillan.,Woo，Bau Yi.,...&Chng，Shu Sin.(2023).Auranofin inhibits virulence pathways in Pseudomonas aeruginosa.Bioorganic and Medicinal Chemistry,79.
|
| MLA |
Yam，Joey Kuok Hoong,et al."Auranofin inhibits virulence pathways in Pseudomonas aeruginosa".Bioorganic and Medicinal Chemistry 79(2023).
|
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