Mediating effect of metabolic diseases on the relationship between hyperuricemia and coronary heart disease

Hu，Yujia1; Li，Jing1; Yin，Chun2; Xu，Lulu1; Li，Siyu1; Chen，Yarong1; Wang，Yufeng2; Cheng，Zhiyuan3; Bai，Yana1

2023-02-01

10.1016/j.numecd.2022.11.005

Nutrition, Metabolism and Cardiovascular Diseases   Impact Factor & Quartile

0939-4753

1590-3729

Background and aims: Studies have shown that elevated serum uric acid (SUA) may increase the risk of coronary heart disease (CHD). However, it is still disputable how mediate effects between metabolic diseases and hyperuricemia affect the incidence of CHD. This study aimed to explore whether metabolic diseases may mediate the connection from hyperuricemia at baseline to the elevated incidence risk of CHD during follow-ups. Methods and Results: Based on the Jinchang cohort, 48 001 subjects were followed for 9 years between June 2011 and December 2019. Multivariate-adjusted Cox regression models were applied to estimate hazard ratios (HRs) of CHD with 95% confidence intervals (CIs). Significantly increased risks of CHD were observed in hyperuricemia (HR:1.46, 95%CI:1.28, 1.67) when compared with normouricemia population. The mediating effect model further demonstrated that metabolic diseases could mediate the association between hyperuricemia and CHD pathogenesis, partially for the combined metabolic diseases with mediation effects of 45.12%, 25.24% for hypertension, 28.58% for overweight or obese status, 29.05% for hypertriglyceridemia, 6.70% for hypercholesterolemia, 3.52% for low high density lipoprotein cholesterol (HDL-C), and 6.51% for high low density lipoprotein cholesterol (LDL-C), respectively. Conclusions: Hyperuricemia significantly increased the risk of incident CHD, and this association was partly mediated by metabolic diseases.

Coronary heart disease Hyperuricemia Jingchang cohort Metabolic diseases

English

Others

Lanzhou University[2018ldbrzd008];National Natural Science Foundation of China[81673248];

CLINICAL MEDICINE

2-s2.0-85145683851

Scopus

1.Department of Epidemiology and Statistics,School of Public Health,Lanzhou University,Lanzhou,199 Donggang West Street, Gansu,730000,China
2.Workers' Hospital of Jinchuan Group Co.,Ltd.,Jinchang,Gansu,China
3.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Street,518055,China

Hu，Yujia,Li，Jing,Yin，Chun,et al. Mediating effect of metabolic diseases on the relationship between hyperuricemia and coronary heart disease[J]. Nutrition, Metabolism and Cardiovascular Diseases,2023,33(2):315-322.

Hu，Yujia.,Li，Jing.,Yin，Chun.,Xu，Lulu.,Li，Siyu.,...&Bai，Yana.(2023).Mediating effect of metabolic diseases on the relationship between hyperuricemia and coronary heart disease.Nutrition, Metabolism and Cardiovascular Diseases,33(2),315-322.

Hu，Yujia,et al."Mediating effect of metabolic diseases on the relationship between hyperuricemia and coronary heart disease".Nutrition, Metabolism and Cardiovascular Diseases 33.2(2023):315-322.