Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly
|Corresponding Author||Qi，Jianxun; Wong，Catherine C.L.; Zhang，Xinzheng; Wang，Peiyi; Qin，Qiwei; Gao，George F.|
|Joint first author||Zhao，Zhennan; Huang，Youhua; Liu，Congcong; Zhu，Dongjie; Gao，Shuaixin|
Singapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a highly pathogenic iridovirid. SGIV infection results in massive economic losses to the aquaculture industry and significantly threatens global biodiversity. In recent years, high morbidity and mortality in aquatic animals have been caused by iridovirid infections worldwide. Effective control and prevention strategies are urgently needed. Here, we present a near-atomic architecture of the SGIV capsid and identify eight types of capsid proteins. The viral inner membrane-integrated anchor protein colocalizes with the endoplasmic reticulum (ER), supporting the hypothesis that the biogenesis of the inner membrane is associated with the ER. Additionally, immunofluorescence assays indicate minor capsid proteins (mCPs) could form various building blocks with major capsid proteins (MCPs) before the formation of a viral factory (VF). These results expand our understanding of the capsid assembly of NCVs and provide more targets for vaccine and drug design to fight iridovirid infections.
NI Journal Papers
共同第一 ; Corresponding
Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29010202] ; National Natural Science Foundation of China["32150005","CARS-47-G16"] ; Medical and Scientific Innovation Project of the Chinese Academy of Medical Science ; null[2022-12M-1-004]
|WOS Research Area|
Science & Technology - Other Topics
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Biology|
1.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,100101,China
2.College of Marine Sciences,South China Agricultural University,Guangdong Laboratory for Lingnan Modern Agriculture,Guangzhou,510642,China
3.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
4.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Shenzhen,518112,China
5.School of Life Science,University of Science and Technology of China,Hefei,230026,China
6.National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,100101,China
7.Clinical Research Institute,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,100730,China
8.Ohio State University,Columbus,Department of Human Sciences & James Comprehensive Cancer Center,43210,United States
9.Perelman School of Medicine,University of Pennsylvania,Philadelphia,19104,United States
10.University of Chinese Academy of Sciences,100049,China
11.Beijing Life Science Academy,102209,China
12.Clinical Research Institute,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,100730,China
|Corresponding Author Affilication||Department of Biology; School of Life Sciences|
Zhao，Zhennan,Huang，Youhua,Liu，Congcong,et al. Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly[J]. Nature communications,2023,14(1).
Zhao，Zhennan.,Huang，Youhua.,Liu，Congcong.,Zhu，Dongjie.,Gao，Shuaixin.,...&Gao，George F..(2023).Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.Nature communications,14(1).
Zhao，Zhennan,et al."Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly".Nature communications 14.1(2023).
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