| Title | 新的SERPINC1无义突变致抗凝血酶Ⅲ缺乏症并肺血栓栓塞症1例 |
| Alternative Title | A novel SERPINC1 nonsense mutation causing an-tithrombin Ⅲ deficiency and pulmonary thromboem-bolism:a case report
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| Author | |
| Publication Years | 2023
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| DOI | |
| Source Title | |
| ISSN | 1001-5213
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| Volume | 43Issue:3Pages:344-346 |
| Abstract | 抗凝血酶Ⅲ(antithrombin Ⅲ,AT Ⅲ)是人体凝血系统重要的抗凝血因子,可与肝素类药物结合形成药物-AT Ⅲ复合物,增强对活化凝血因子Ⅱ、Ⅸ、X、Ⅻ的抑制作用[1].AT Ⅲ缺乏是静脉血栓栓塞症(venous thromboembolism,VTE)的主要遗传性危险因素,可致肺血栓栓塞症(pulmona-ry thromboembolism,PTE).有文献报道遗传性AT Ⅲ缺乏症与SERPINC1基因突变密切相关[2-4].本文报道1例新的SERPINC1无义突变致严重的Ⅰ型遗传性ATⅢ缺乏症并肺血栓栓塞症病例,并结合相关指南及临床研究对其抗凝治疗进行探讨,为该类疾病诊治提供参考. |
| Keywords | |
| URL | [Source Record] |
| Language | Chinese
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| SUSTech Authorship | First
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| Funding Project | 2021A23:广东省医院药学研究基金
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| Data Source | WanFang
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| WanFangID | zgyyyx202303020
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| Citation statistics |
Cited Times [WOS]:0
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| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/524998 |
| Department | Southern University of Science and Technology |
| Affiliation | 1.深圳市人民医院/暨南大学第二临床医学院/南方科技大学附属第一医院药学部,广东深圳 518020 2.深圳市人民医院/暨南大学第二临床医学院/南方科技大学附属第一医院呼吸与危重症医学科,广东深圳 518020 |
| First Author Affilication | Southern University of Science and Technology |
| First Author's First Affilication | Southern University of Science and Technology |
| Recommended Citation GB/T 7714 |
周桂保,古嘉瑜,陈秋玲,等. 新的SERPINC1无义突变致抗凝血酶Ⅲ缺乏症并肺血栓栓塞症1例[J]. 中国医院药学杂志,2023,43(3):344-346.
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| APA |
周桂保,古嘉瑜,陈秋玲,李凯,刘盛国,&谢守霞.(2023).新的SERPINC1无义突变致抗凝血酶Ⅲ缺乏症并肺血栓栓塞症1例.中国医院药学杂志,43(3),344-346.
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| MLA |
周桂保,et al."新的SERPINC1无义突变致抗凝血酶Ⅲ缺乏症并肺血栓栓塞症1例".中国医院药学杂志 43.3(2023):344-346.
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