The alterations in multiple neurophysiological procedures are associated with frailty phenotype in older adults

Jiang, Xin1,2,3; Zhou, Junhong4,5,6; Yu, Chengyuan1,2,3; Chen, Wenbo1,2,3; Huang, Baofeng1,2,3; Chen, Yurong1; Zhong, Lilian1,2,3; Guo, Yi2,3,7,8; Geng, Qingshan1,2,3; Cai, Yurun9

2023-03-28

10.3389/fnagi.2023.1063322

FRONTIERS IN AGING NEUROSCIENCE   Impact Factor & Quartile

1663-4365

BackgroundOlder adults oftentimes suffer from the conditions in multiple physiologic systems, interfering with their daily function and thus contributing to physical frailty. The contributions of such multisystem conditions to physical frailty have not been well characterized. MethodsIn this study, 442 (mean age = 71.4 +/- 8.1 years, 235 women) participants completed the assessment of frailty syndromes, including unintentional weight loss, exhaustion, slowness, low activity, and weakness, and were categorized into frail (>= 3 conditions), pre-frail (1 or 2 conditions), and robust (no condition) status. Multisystem conditions including cardiovascular diseases, vascular function, hypertension, diabetes, sleep disorders, sarcopenia, cognitive impairment, and chronic pain were assessed. Structural equation modeling examined the interrelationships between these conditions and their associations with frailty syndromes. ResultsFifty (11.3%) participants were frail, 212 (48.0%) were pre-frail, and 180 (40.7%) were robust. We observed that worse vascular function was directly associated with higher risk of slowness [standardized coefficient (SC) = -0.419, p < 0.001], weakness (SC = -0.367, p < 0.001), and exhaustion (SC = -0.347, p < 0.001). Sarcopenia was associated with both slowness (SC = 0.132, p = 0.011) and weakness (SC = 0.217, p = 0.001). Chronic pain, poor sleep quality, and cognitive impairment were associated with exhaustion (SC = 0.263, p < 0.001; SC = 0.143, p = 0.016; SC = 0.178, p = 0.004, respectively). The multinomial logistic regression showed that greater number of these conditions were associated with increased probability of being frail (odds ratio>1.23, p < 0.032). ConclusionThese findings in this pilot study provide novel insights into how multisystem conditions are associated with each other and with frailty in older adults. Future longitudinal studies are warranted to explore how the changes in these health conditions alter frailty status.

neurophysiological alterations multisystem comorbidities vascular function frailty phenotype frail status

SCI

English

Corresponding

Sustainable Development Science and Technology Project of Shenzhen Science and Technology Innovation Commission["KCXFZ20201221173411032","KCXFZ20201221173400001"] ; Basic Research Project of Shenzhen Natural Science Foundation, Shenzhen Science and Technology Planning Project[JCYJ20190807145209306] ; Natural Science Foundation of Guangdong Province[2021A1515010983] ; "Five Threes" Clinical Research Program of Shenzhen People's Hospital[SYWGSLCYJ202204] ; Shenzhen Key Medical Discipline Construction Fund["SZXK012","SZXK005"] ; National Institute on Aging[1K01AG075180-01]

Geriatrics & Gerontology ; Neurosciences & Neurology

Geriatrics & Gerontology ; Neurosciences

WOS:000966624400001

FRONTIERS MEDIA SA

Web of Science

1.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
4.Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res, Roslindale, MA USA
5.Beth Israel Deaconess Med Ctr, Div Gerontol, Boston, MA USA
6.Harvard Med Sch, Boston, MA USA
7.Shenzhen Peoples Hosp, Dept Neurol, Shenzhen, Guangdong, Peoples R China
8.Shenzhen Bay Lab, Shenzhen, Guangdong, Peoples R China
9.Univ Pittsburgh, Dept Hlth & Community Syst, Sch Nursing, Pittsburgh, PA USA

Jiang, Xin,Zhou, Junhong,Yu, Chengyuan,et al. The alterations in multiple neurophysiological procedures are associated with frailty phenotype in older adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2023,15.

Jiang, Xin.,Zhou, Junhong.,Yu, Chengyuan.,Chen, Wenbo.,Huang, Baofeng.,...&Cai, Yurun.(2023).The alterations in multiple neurophysiological procedures are associated with frailty phenotype in older adults.FRONTIERS IN AGING NEUROSCIENCE,15.

Jiang, Xin,et al."The alterations in multiple neurophysiological procedures are associated with frailty phenotype in older adults".FRONTIERS IN AGING NEUROSCIENCE 15(2023).