| Title | 异常凝血酶原和甲胎蛋白异质体比率联合检测在AFP阴性HBV相关HCC诊断中的作用 |
| Alternative Title | Role of protein induced by vitamin K absence/antagonist-Ⅱ and alpha-fetoprotein-L3 ratio combination in the diagnosis of HBV-related HCC with negative AFP
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| Author | |
| Publication Years | 2022
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| DOI | |
| Source Title | |
| ISSN | 2096-2738
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| Volume | 7Issue:4Pages:25-28 |
| Abstract | 目的 探讨异常凝血酶原(PIVKA-Ⅱ)及甲胎蛋白异质体比率(AFP-L3％)对甲胎蛋白(AFP)阴性HBV相关肝细胞癌(HCC)的诊断价值.方法 选取2018年1月至2021年10月在深圳市第三人民医院就诊AFP阴性HBV相关HCC患者(HCC组)86例,HBV相关良性肝病患者(良性肝病组)69例,健康对照者(对照组)56例,检测血清PIVKA-Ⅱ、AFP-L3％水平并进行统计分析,绘制受试者操作特征曲线(ROC曲线)分析PIVKA-Ⅱ、AFP-L3％单独及联合检测对AFP阴性HBV相关HCC的诊断效能.结果 三组间血清PIVKA-Ⅱ、AFP-L3％比较,差异均有统计学意义(P<0.05);HCC组PIVKA-Ⅱ、AFP-L3％均高于良性肝病组及对照组,差异有统计学意义(P<0.05);PIVKA-Ⅱ诊断AFP阴性HBV相关HCC的曲线下面积(AUC)0.703,灵敏度为54.7％、特异度为91.2％,最佳截断值41.63mAU/ml;AFP-L3％的AUC面积0.681,灵敏度为60.5％、特异度为84.0％,最佳截断值5.96％;联合AFP-L3％和PIVKA-Ⅱ检测的AUC面积0.771,灵敏度为74.7％、特异度为82.4％.结论 在AFP阴性HBV相关HCC诊断上,PIVKA-Ⅱ、AFP-L3％均有意义,联合检测有助于提高AFP阴性HBV相关HCC的诊断效能,为AFP阴性HBV相关HCC早期诊断提供理论依据. |
| Keywords | |
| URL | [Source Record] |
| Language | Chinese
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| SUSTech Authorship | Others
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| Funding Project | SZXK076:深圳市医学重点学科建设经费资助
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| Data Source | WanFang
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| WanFangID | xfcrbdzzz202204007
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| Citation statistics |
Cited Times [WOS]:0
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| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/531368 |
| Department | The Third People's Hospital of Shenzhen |
| Affiliation | 1.深圳市第三人民医院/南方科技大学附属第二医院肝病医学中心,广东 深圳 518000 2.深圳市龙岗中心医院,广东 深圳518000 |
| Recommended Citation GB/T 7714 |
陈圆圆,程文兵,陈川铁,等. 异常凝血酶原和甲胎蛋白异质体比率联合检测在AFP阴性HBV相关HCC诊断中的作用[J]. 新发传染病电子杂志,2022,7(4):25-28.
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| APA |
陈圆圆.,程文兵.,陈川铁.,朱质斌.,黄德良.,...&陈军.(2022).异常凝血酶原和甲胎蛋白异质体比率联合检测在AFP阴性HBV相关HCC诊断中的作用.新发传染病电子杂志,7(4),25-28.
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| MLA |
陈圆圆,et al."异常凝血酶原和甲胎蛋白异质体比率联合检测在AFP阴性HBV相关HCC诊断中的作用".新发传染病电子杂志 7.4(2022):25-28.
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