| Title | 磷酸二酯酶抑制剂或其药物组合物在制备治疗新型冠状病毒肺炎的药物中的应用 |
| Alternative Title | Application of phosphodiesterase inhibitor or pharmaceutical composition thereof in preparation of medicines for treating novel coronavirus pneumonia
|
| Author | |
| First Inventor | 胡宇慧
|
| Original applicant | 南方科技大学
; 广州医科大学附属第一医院(广州呼吸中心)
|
| First applicant | 南方科技大学
|
| Address of First applicant | 518055 广东省深圳市南山区西丽学苑大道1088号
|
| Current applicant | 南方科技大学
; 广州医科大学附属第一医院(广州呼吸中心)
|
| Address of Current applicant | 518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
|
| First Current Applicant | 南方科技大学
|
| Address of First Current Applicant | 518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
|
| Application Number | CN202010769251.1
|
| Application Date | 2020-08-03
|
| Open (Notice) Number | CN114053280A
|
| Date Available | 2022-02-18
|
| Status of Patent | 实质审查
|
| Legal Date | 2022-03-08
|
| Subtype | 发明申请
|
| SUSTech Authorship | First
|
| Abstract | 本发明提供磷酸二酯酶抑制剂或其药物组合物在制备治疗新型冠状病毒肺炎的药物的应用，本发明通过系统生物学的筛选以及细胞水平实验验证了扎达维林、匹莫苯、克立硼罗能够在细胞水平上不同程度地抑制新型冠状病毒的增殖，其中扎达维林的抗新冠病毒效果最强，匹莫苯次之，三种药物均可用于制备治疗新型冠状病毒肺炎的药物。 |
| Other Abstract | The invention provides the application of a phosphodiesterase inhibitor or a pharmaceutical composition of the phosphodiesterase inhibitor in preparation of medicines for treating novel coronavirus pneumonia, screening of systematic biology and cellular level experiments verify that zardaverine, Pimobendan and crisaborole can inhibit proliferation of novel coronavirus to different degrees on the cellular level; wherein zardaverine has the strongest anti-new coronavirus effect, Pimobendan has the second anti-new coronavirus effect, and zardaverine, Pimobendan and crisaborole can be used for preparing medicines for treating novel coronavirus pneumonia. |
| CPC Classification Number | A61K31/50
; A61K31/501
; A61K31/69
; A61P11/00
; A61P31/14
; A61K2300/00
|
| IPC Classification Number | A61K31/50
; A61K31/501
; A61K31/69
; A61P11/00
; A61P31/14
|
| INPADOC Legal Status | （ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-03-08][CN]
|
| INPADOC Patent Family Count | 1
|
| Extended Patent Family Count | 1
|
| Priority date | 2020-08-03
|
| Patent Agent | 潘登
|
| Agency | 北京品源专利代理有限公司
|
| URL | [Source Record] |
| Data Source | PatSnap
|
| Document Type | Patent |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/531589 |
| Department | Department of Pharmacology 生命科学学院_生物系 |
| Recommended Citation GB/T 7714 |
胡宇慧,赵金存,李云飞,等. 磷酸二酯酶抑制剂或其药物组合物在制备治疗新型冠状病毒肺炎的药物中的应用.
|
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