南方科技大学知识苑(SUSTech KC): 一种微流控芯片及其制作方法

Title	一种微流控芯片及其制作方法
Alternative Title	Micro-fluidic chip and manufacturing method thereof
Author	章洪永; 黄楠
First Inventor	章洪永
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区西丽学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202011553975.9
Application Date	2020-12-24
Open (Notice) Number	CN112538430A
Date Available	2021-03-23
Status of Patent	实质审查
Legal Date	2021-04-09
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明实施例公开了一种微流控芯片及其制作方法，所述微流控芯片包括：施压层，包括通气孔和通气槽，所述通气孔用于通入气体至所述通气槽，所述通气槽内基于通入的气体产生气压；捕获层，包括捕获通道，所述捕获通道用于通入多个待施压样品；形变层，设于所述施压层和所述捕获层之间，用于根据所述气压产生形变，以对所述捕获层中的多个待施压样品施加机械力。本发明实施例提供的微流控芯片通过捕获层、形变层和施压层实现了对细胞球的挤压，通过控制施压层通入的气体的压力可以控制细胞所受到的挤压力，从而实现细胞受力的可控性。
Other Abstract	The embodiment of the invention discloses a micro-fluidic chip and a manufacturing method thereof. The micro-fluidic chip comprises a pressurization layer comprising a vent hole and a vent groove, wherein the vent hole is used for introducing gas into the vent groove, and the vent groove generates a gas pressure based on the introduced gas; a capture layer comprising a capture channel that is usedfor introducing a plurality of samples to be pressurized; and a deformation layer arranged between the pressurization layer and the capture layer and used for generating deformation according to theair pressure so as to apply mechanical force to the plurality of samples to be pressurized in the capture layer. According to the micro-fluidic chip provided by the embodiment of the invention, cell spheres are extruded through the capture layer, the deformation layer and the pressurization layer, and the extrusion force on cells can be controlled by controlling the pressure of gas introduced by the pressurization layer, so that the controllability of cell stress is realized.
CPC Classification Number	C12M23/16 ; C12M29/06 ; C12M35/04 ; B01L3/502707
IPC Classification Number	C12M3/00 ; C12M1/04 ; B01L3/00
INPADOC Legal Status	（CHANGE OF INVENTOR OR DESIGNER INFORMATION）[2023-01-13][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2020-12-24
Patent Agent	潘登
Agency	北京品源专利代理有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/531649
Department	Southern University of Science and Technology
Recommended Citation GB/T 7714	章洪永,黄楠. 一种微流控芯片及其制作方法.

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