南方科技大学知识苑(SUSTech KC): 可多次写入及擦除的DNA存储条带

Title	可多次写入及擦除的DNA存储条带
Alternative Title	DNA (deoxyribonucleic acid) storage strip capable of being written and erased for multiple times
Author	蒋兴宇; 李健恺
First Inventor	蒋兴宇
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202111674161.5
Application Date	2021-12-31
Open (Notice) Number	CN114360600A
Date Available	2022-04-15
Status of Patent	实质审查
Legal Date	2022-05-03
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开了可多次写入及擦除的存储条带。本申请的第一方面，提供存储条带，该存储条带包括：条带基底，条带基底上设有索引层，索引层包括若干索引柱，若干索引柱被配置为形成索引图案，若干索引柱之间的条带基底用于固定寡核苷酸，寡核苷酸用于特异性结合待存储的核酸片段；保护层，保护层位于条带基底远离索引层的一侧，保护层被配置为在存储条带卷绕时能够封闭索引柱。索引图案可以将条带分割成若干个不同区域，可以根据不同分区的索引图案对相应区域进行识别以达到随机索引的目的。通过寡核苷酸使核酸片段可以特异性结合到存储条带上完成写入，并且可以在一定的外部条件进行读取或直接擦除。
Other Abstract	The invention discloses a memory strip capable of being written and erased multiple times. In a first aspect of the present application, a memory strip is provided, the memory strip comprises: a strip substrate, the strip substrate is provided with an index layer, the index layer comprises a plurality of index columns, the plurality of index columns are configured to form an index pattern, the strip substrate among the plurality of index columns is used for fixing oligonucleotides, and the oligonucleotides are used for specific binding to a nucleic acid fragment to be stored; the protection layer is located on the side, away from the index layer, of the strip substrate, and the protection layer is configured to be capable of sealing the index column when the storage strip is wound. The index patterns can divide the strip into a plurality of different areas, and the corresponding areas can be identified according to the index patterns of different partitions so as to achieve the purpose of random indexing. Through oligonucleotides, nucleic acid fragments can be specifically bound to a storage strip to complete writing, and can be read or directly erased under certain external conditions.
IPC Classification Number	G11C11/54 ; G16B30/00 ; G16B50/00 ; C12Q1/6869
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-05-03][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2021-12-31
Patent Agent	刘燚
Agency	广州嘉权专利商标事务所有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/532358
Department	Department of Biomedical Engineering
Recommended Citation GB/T 7714	蒋兴宇,李健恺. 可多次写入及擦除的DNA存储条带.

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