南方科技大学知识苑(SUSTech KC): 一种用于抗原蛋白检测的纳米颗粒及其制备方法

Title	一种用于抗原蛋白检测的纳米颗粒及其制备方法
Alternative Title	Nanoparticles for antigen protein detection and preparation method thereof
Author	权泽卫; 王昊全; 张妍; 何美莹; 李晨 ; 陈昱霖
First Inventor	权泽卫
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202210302558.X
Application Date	2022-03-25
Open (Notice) Number	CN114839366A
Date Available	2022-08-02
Status of Patent	实质审查
Legal Date	2022-08-19
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开一种用于抗原蛋白检测的纳米颗粒及其制备方法和试纸条，包括提供初始纳米颗粒溶液；将所述初始纳米颗粒溶液与拉曼报告分子溶液混合进行偶联反应，得到表面修饰的纳米颗粒溶液，所述拉曼报告分子的官能团同时包含巯基和氰基；以及将所述表面修饰的纳米颗粒溶液与抗体溶液混合进行静电吸附，得到用于抗原蛋白检测的纳米颗粒溶液。通过所述用于抗原蛋白检测的纳米颗粒，可以特异性地捕获病毒的抗原蛋白，从而结合免疫层析法和拉曼光谱表征快速且高效地检出特定抗原蛋白，实现快速且准确地检测特定病毒。
Other Abstract	The invention discloses nanoparticles for antigen protein detection, a preparation method of the nanoparticles and a test strip. The preparation method comprises the following steps: providing an initial nanoparticle solution; the initial nano-particle solution and a Raman reporter molecule solution are mixed for a coupling reaction, a surface-modified nano-particle solution is obtained, and functional groups of Raman reporter molecules contain sulfydryl and cyano at the same time; and mixing the surface-modified nanoparticle solution with an antibody solution, and carrying out electrostatic adsorption to obtain the nanoparticle solution for antigen protein detection. According to the nanoparticles for antigen protein detection, the antigen protein of a virus can be specifically captured, so that the specific antigen protein can be rapidly and efficiently detected by combining immunochromatography and Raman spectrum characterization, and the specific virus can be rapidly and accurately detected.
CPC Classification Number	G01N33/54346 ; G01N33/54387 ; G01N33/56983 ; G01N33/532 ; B82Y5/00 ; G01N2469/10 ; Y02A50/30
IPC Classification Number	G01N33/543 ; G01N33/532 ; G01N33/569 ; B82Y5/00
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-08-19][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2022-03-25
Patent Agent	朱阳波
Agency	深圳市君胜知识产权代理事务所(普通合伙)
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/532393
Department	Department of Chemistry
Recommended Citation GB/T 7714	权泽卫,王昊全,张妍,等. 一种用于抗原蛋白检测的纳米颗粒及其制备方法.

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