| Title | 一种C-四链体脱氧核酶及其制备方法和应用 |
| Alternative Title | C-quadruplex DNAzyme (i-motif DNAzyme) as well as preparation method and application thereof
|
| Author | |
| First Inventor | 蒋兴宇
|
| Original applicant | 南方科技大学
|
| First applicant | 南方科技大学
|
| Address of First applicant | 518055 广东省深圳市南山区西丽学苑大道1088号
|
| Current applicant | 南方科技大学
|
| Address of Current applicant | 518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
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| First Current Applicant | 南方科技大学
|
| Address of First Current Applicant | 518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
|
| Application Number | CN202010657392.4
|
| Application Date | 2020-07-09
|
| Open (Notice) Number | CN111763673A
|
| Date Available | 2020-10-13
|
| Status of Patent | 实质审查
|
| Legal Date | 2020-10-30
|
| Subtype | 发明申请
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| SUSTech Authorship | First
|
| Abstract | 本发明提供一种C‑四链体脱氧核酶及其制备方法和应用。所述C‑四链体脱氧核酶为C‑四链体与过氧化物酶活性材料组合形成的复合物。其中，C‑四链体由富含胞嘧啶的核苷酸序列折叠组装得到。本发明提供的C‑四链体脱氧核酶相比同浓度的过氧化物酶活性材料，具有更高的催化活性，在催化相同浓度的酶反应底物时，发生反应的速率更快，且具有较好的特异性和灵敏度，是一种制备简单、成本低廉且催化活性好的纳米酶。 |
| Other Abstract | The invention provides a C-quadruplex DNAzyme (i-motif DNAzyme) as well as a preparation method and application thereof. The i-motif DNAzyme is a complex formed by the combination of a C-quadruplex and a peroxidase active material, wherein the C-quadruplex is obtained by folding and assembling a nucleotide sequence rich in cytosine. The i-motif DNAzyme has higher catalytic activity than the peroxidase active material of the same concentration, has a faster reaction rate when catalyzing reactions with enzyme reaction substrates of the same concentration, has good specificity and sensitivity, and is a nano-enzyme which is simple to prepare, low in cost and good in catalytic activity. |
| CPC Classification Number | C12N15/113
; C12Q1/25
; B01J31/34
; B01J31/0271
; C12N2310/127
; C12N2330/30
; B01J2231/70
|
| IPC Classification Number | C12N15/113
; C12Q1/25
; B01J31/34
; B01J31/02
|
| INPADOC Legal Status | （PUBLICATION）[2020-10-13][CN]
|
| INPADOC Patent Family Count | 1
|
| Extended Patent Family Count | 1
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| Priority date | 2020-07-09
|
| Patent Agent | 潘登
|
| Agency | 北京品源专利代理有限公司
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| URL | [Source Record] |
| Data Source | PatSnap
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| Document Type | Patent |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/532489 |
| Department | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
蒋兴宇,詹深山. 一种C-四链体脱氧核酶及其制备方法和应用.
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