南方科技大学知识苑(SUSTech KC): 一种光调控嗜中性粒细胞在治疗癌症的药物中的应用

Title	一种光调控嗜中性粒细胞在治疗癌症的药物中的应用
Alternative Title	Application of light controlled neutrophilic granulocytes in medicines for treating cancers
Author	汪会荣; 黄巍; 叶德全
First Inventor	汪会荣
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区学苑大道1088号 (广东,深圳,南山区)
Application Number	CN201910978876.6
Application Date	2019-10-15
Open (Notice) Number	CN110755449A
Date Available	2020-02-07
Status of Patent	实质审查
Legal Date	2020-03-03
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开了一种光调控嗜中性粒细胞在治疗癌症的药物中的应用，其中，所述光调控嗜中性粒细胞在光照条件下表达用于招募并扩增免疫细胞的细胞因子。本发明利用嗜中性粒细胞自身可以被肿瘤招募的能力，通过在嗜中性粒细胞中表达光调控细胞因子系统，在体外验证光控制不同时间及强度下，测定改造后的细胞释放不同细胞因子的水平，以及这些细胞因子对肿瘤细胞的促进或者抑制作用。从而实现人为可控的在肿瘤细胞周边释放细胞因子并招募其他免疫细胞，继而可影响肿瘤的生长和增殖，最终达到改变肿瘤细胞生长微环境的目的。
Other Abstract	The invention discloses application of light controlled neutrophilic granulocytes in medicines for treating cancers. The light controlled neutrophilic granulocytes can express cytokines for recruitingand amplifying immune cells under a light condition. The performance that neutrophilic granulocytes can be recruited by tumors is utilized, a light controlled cytokine system is expressed in the neutrophilic granulocytes and is used for in-vitro verifying that levels of different cytokines released by modified cells and promoting and inhibiting effects of the cytokines on tumor cells can be detected under different times and strengths of light control. Therefore, cytokine releasing and other immune cell recruiting around the tumor cells can be realized in a human-controlled manner, growth andproliferation of tumor cells can be influenced, and the aim of changing the growing microenvironment of the tumor cells can be achieved finally.
CPC Classification Number	A61K35/15 ; A61P35/00 ; C12N5/0642 ; C12N15/86 ; C12N2740/15043 ; C12N2510/00 ; Y02A50/30
IPC Classification Number	A61K35/15 ; A61P35/00 ; C12N15/867 ; C12N5/10
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2020-03-03][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2019-10-15
Patent Agent	王永文
Agency	深圳市君胜知识产权代理事务所(普通合伙)
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/532566
Department	Department of Biology
Recommended Citation GB/T 7714	汪会荣,黄巍,叶德全. 一种光调控嗜中性粒细胞在治疗癌症的药物中的应用.

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